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A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function

Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this n...

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Autores principales: Rincon, Mercedes, Pereira, Felipe Valença
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032237/
https://www.ncbi.nlm.nih.gov/pubmed/29866996
http://dx.doi.org/10.3390/ijms19061656
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author Rincon, Mercedes
Pereira, Felipe Valença
author_facet Rincon, Mercedes
Pereira, Felipe Valença
author_sort Rincon, Mercedes
collection PubMed
description Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this non-conventional function of Stat3 in lymphocytes. From this perspective, we review what is known about Stat3 as a transcription factor and what is known and unknown about mitochondrial Stat3 (mitoStat3) in lymphocytes. We also provide a framework to consider how some of the functions previously assigned to Stat3 as regulator of gene transcription could be mediated by mitoStat3 in lymphocytes. The goal of this review is to stimulate interest for future studies investigating mitoStat3 in the immune response that could lead to the generation of alternative pharmacological inhibitors of mitoStat3 for the treatment of chronic inflammatory diseases.
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spelling pubmed-60322372018-07-13 A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function Rincon, Mercedes Pereira, Felipe Valença Int J Mol Sci Review Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this non-conventional function of Stat3 in lymphocytes. From this perspective, we review what is known about Stat3 as a transcription factor and what is known and unknown about mitochondrial Stat3 (mitoStat3) in lymphocytes. We also provide a framework to consider how some of the functions previously assigned to Stat3 as regulator of gene transcription could be mediated by mitoStat3 in lymphocytes. The goal of this review is to stimulate interest for future studies investigating mitoStat3 in the immune response that could lead to the generation of alternative pharmacological inhibitors of mitoStat3 for the treatment of chronic inflammatory diseases. MDPI 2018-06-04 /pmc/articles/PMC6032237/ /pubmed/29866996 http://dx.doi.org/10.3390/ijms19061656 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rincon, Mercedes
Pereira, Felipe Valença
A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title_full A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title_fullStr A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title_full_unstemmed A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title_short A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
title_sort new perspective: mitochondrial stat3 as a regulator for lymphocyte function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032237/
https://www.ncbi.nlm.nih.gov/pubmed/29866996
http://dx.doi.org/10.3390/ijms19061656
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