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A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function
Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this n...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032237/ https://www.ncbi.nlm.nih.gov/pubmed/29866996 http://dx.doi.org/10.3390/ijms19061656 |
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author | Rincon, Mercedes Pereira, Felipe Valença |
author_facet | Rincon, Mercedes Pereira, Felipe Valença |
author_sort | Rincon, Mercedes |
collection | PubMed |
description | Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this non-conventional function of Stat3 in lymphocytes. From this perspective, we review what is known about Stat3 as a transcription factor and what is known and unknown about mitochondrial Stat3 (mitoStat3) in lymphocytes. We also provide a framework to consider how some of the functions previously assigned to Stat3 as regulator of gene transcription could be mediated by mitoStat3 in lymphocytes. The goal of this review is to stimulate interest for future studies investigating mitoStat3 in the immune response that could lead to the generation of alternative pharmacological inhibitors of mitoStat3 for the treatment of chronic inflammatory diseases. |
format | Online Article Text |
id | pubmed-6032237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60322372018-07-13 A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function Rincon, Mercedes Pereira, Felipe Valença Int J Mol Sci Review Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metabolism, only a few studies have investigated this non-conventional function of Stat3 in lymphocytes. From this perspective, we review what is known about Stat3 as a transcription factor and what is known and unknown about mitochondrial Stat3 (mitoStat3) in lymphocytes. We also provide a framework to consider how some of the functions previously assigned to Stat3 as regulator of gene transcription could be mediated by mitoStat3 in lymphocytes. The goal of this review is to stimulate interest for future studies investigating mitoStat3 in the immune response that could lead to the generation of alternative pharmacological inhibitors of mitoStat3 for the treatment of chronic inflammatory diseases. MDPI 2018-06-04 /pmc/articles/PMC6032237/ /pubmed/29866996 http://dx.doi.org/10.3390/ijms19061656 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rincon, Mercedes Pereira, Felipe Valença A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title | A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title_full | A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title_fullStr | A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title_full_unstemmed | A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title_short | A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function |
title_sort | new perspective: mitochondrial stat3 as a regulator for lymphocyte function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032237/ https://www.ncbi.nlm.nih.gov/pubmed/29866996 http://dx.doi.org/10.3390/ijms19061656 |
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