Cargando…
Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females
IgE sensitisation has increased significantly over the last decades and is a crucial factor in the development of allergic diseases. IgE antibodies are produced by B cells through the process of antigen presentation by dendritic cells, subsequent differentiation of CD4(+) Th2 cells, and class switch...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032271/ https://www.ncbi.nlm.nih.gov/pubmed/29882879 http://dx.doi.org/10.3390/ijms19061554 |
_version_ | 1783337475561750528 |
---|---|
author | Leffler, Jonatan Stumbles, Philip A. Strickland, Deborah H. |
author_facet | Leffler, Jonatan Stumbles, Philip A. Strickland, Deborah H. |
author_sort | Leffler, Jonatan |
collection | PubMed |
description | IgE sensitisation has increased significantly over the last decades and is a crucial factor in the development of allergic diseases. IgE antibodies are produced by B cells through the process of antigen presentation by dendritic cells, subsequent differentiation of CD4(+) Th2 cells, and class switching in B cells. However, many of the factors regulating these processes remain unclear. These processes affect males and females differently, resulting in a significantly higher prevalence of IgE sensitisation in males compared to females from an early age. Before the onset of puberty, this increased prevalence of IgE sensitisation is also associated with a higher prevalence of clinical symptoms in males; however, after puberty, females experience a surge in the incidence of allergic symptoms. This is particularly apparent in allergic asthma, but also in other allergic diseases such as food and contact allergies. This has been partly attributed to the pro- versus anti-allergic effects of female versus male sex hormones; however, it remains unclear how the expression of sex hormones translates IgE sensitisation into clinical symptoms. In this review, we describe the recent epidemiological findings on IgE sensitisation in male and females and discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system at mucosal surfaces and how sex hormones may be involved in translating IgE sensitisation into clinical manifestations. |
format | Online Article Text |
id | pubmed-6032271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60322712018-07-13 Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females Leffler, Jonatan Stumbles, Philip A. Strickland, Deborah H. Int J Mol Sci Review IgE sensitisation has increased significantly over the last decades and is a crucial factor in the development of allergic diseases. IgE antibodies are produced by B cells through the process of antigen presentation by dendritic cells, subsequent differentiation of CD4(+) Th2 cells, and class switching in B cells. However, many of the factors regulating these processes remain unclear. These processes affect males and females differently, resulting in a significantly higher prevalence of IgE sensitisation in males compared to females from an early age. Before the onset of puberty, this increased prevalence of IgE sensitisation is also associated with a higher prevalence of clinical symptoms in males; however, after puberty, females experience a surge in the incidence of allergic symptoms. This is particularly apparent in allergic asthma, but also in other allergic diseases such as food and contact allergies. This has been partly attributed to the pro- versus anti-allergic effects of female versus male sex hormones; however, it remains unclear how the expression of sex hormones translates IgE sensitisation into clinical symptoms. In this review, we describe the recent epidemiological findings on IgE sensitisation in male and females and discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system at mucosal surfaces and how sex hormones may be involved in translating IgE sensitisation into clinical manifestations. MDPI 2018-05-23 /pmc/articles/PMC6032271/ /pubmed/29882879 http://dx.doi.org/10.3390/ijms19061554 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leffler, Jonatan Stumbles, Philip A. Strickland, Deborah H. Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title_full | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title_fullStr | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title_full_unstemmed | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title_short | Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females |
title_sort | immunological processes driving ige sensitisation and disease development in males and females |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032271/ https://www.ncbi.nlm.nih.gov/pubmed/29882879 http://dx.doi.org/10.3390/ijms19061554 |
work_keys_str_mv | AT lefflerjonatan immunologicalprocessesdrivingigesensitisationanddiseasedevelopmentinmalesandfemales AT stumblesphilipa immunologicalprocessesdrivingigesensitisationanddiseasedevelopmentinmalesandfemales AT stricklanddeborahh immunologicalprocessesdrivingigesensitisationanddiseasedevelopmentinmalesandfemales |