Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function

Liver fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. A high-cholesterol diet is associated with liver fibrosis via the accumulation of free cholesterol in hepatic stellate cells (HSCs). Niemann-Pick type C2 (NPC2) plays an important...

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Detalles Bibliográficos
Autores principales: Wang, Yuan-Hsi, Twu, Yuh-Ching, Wang, Chung-Kwe, Lin, Fu-Zhen, Lee, Chun-Ya, Liao, Yi-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032364/
https://www.ncbi.nlm.nih.gov/pubmed/29874879
http://dx.doi.org/10.3390/ijms19061678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032364/
https://www.ncbi.nlm.nih.gov/pubmed/29874879
http://dx.doi.org/10.3390/ijms19061678

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