Cargando…

Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function

Liver fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. A high-cholesterol diet is associated with liver fibrosis via the accumulation of free cholesterol in hepatic stellate cells (HSCs). Niemann-Pick type C2 (NPC2) plays an important...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yuan-Hsi, Twu, Yuh-Ching, Wang, Chung-Kwe, Lin, Fu-Zhen, Lee, Chun-Ya, Liao, Yi-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032364/ https://www.ncbi.nlm.nih.gov/pubmed/29874879 http://dx.doi.org/10.3390/ijms19061678

Ejemplares similares

Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation
por: Twu, Yuh-Ching, et al.
Publicado: (2016)

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease
por: Torres, Sandra, et al.
Publicado: (2019)

Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver Librosis
por: Lee, Chun-Ya, et al.
Publicado: (2020)

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation
por: Dominko, Kristina, et al.
Publicado: (2021)

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
por: Torres, Sandra, et al.
Publicado: (2017)

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation
por: Torres, Sandra, et al.
Publicado: (2021)

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts
por: Cruz, Dana L., et al.
Publicado: (2021)

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
por: Carette, Jan E., et al.
Publicado: (2011)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
por: Trinh, Michael Nguyen, et al.
Publicado: (2018)

Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells
por: Lange, Yvonne, et al.
Publicado: (2012)

PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport
por: Tamari, Farshad, et al.
Publicado: (2013)

Baculovirus Utilizes Cholesterol Transporter NIEMANN–Pick C1 for Host Cell Entry
por: Li, Zhihong, et al.
Publicado: (2019)

Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-κB Signaling Pathway in Hepatic Stellate Cells
por: Wang, Yuan-Hsi, et al.
Publicado: (2020)

Characterization of Niemann-Pick Type C2 Protein Expression in Multiple Cancers Using a Novel NPC2 Monoclonal Antibody
por: Liao, Yi-Jen, et al.
Publicado: (2013)

HMGCS2 Mediates Ketone Production and Regulates the Proliferation and Metastasis of Hepatocellular Carcinoma
por: Wang, Yuan-Hsi, et al.
Publicado: (2019)

Niemann-Pick disease type C
por: Vanier, Marie T
Publicado: (2010)

Stem Cells and Niemann Pick Disease
por: Andolina, Marino
Publicado: (2014)

Stem Cells in Niemann-Pick Disease
por: Kim, Sun-Jung, et al.
Publicado: (2008)

Niemann-Pick disease and platelet dysfunction
Publicado: (2012)

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
por: Gong, Xin, et al.
Publicado: (2016)

Lysosomal-specific Cholesterol Reduction by Biocleavable Polyrotaxanes for Ameliorating Niemann-Pick Type C Disease
por: Tamura, Atsushi, et al.
Publicado: (2014)

Laboratory diagnosis of the Niemann-Pick type C disease: an inherited neurodegenerative disorder of cholesterol metabolism
por: Sitarska, Dominika, et al.
Publicado: (2019)

Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
por: Zeng, Jun, et al.
Publicado: (2022)

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
por: Yamada, Yusei, et al.
Publicado: (2023)

Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes
por: Canonico, Barbara, et al.
Publicado: (2016)

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells
por: Li, Rong, et al.
Publicado: (2017)

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma
por: Chen, Ke-Ji, et al.
Publicado: (2018)

Niemann-Pick Disease: An Approach for Diagnosis in Adulthood
por: Patiño-Escobar, Bonell, et al.
Publicado: (2019)

Corrigendum to “Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation” [Redox Biol. 2021 45 102052]
por: Torres, S., et al.
Publicado: (2022)

The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts
Publicado: (1989)

Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O
por: Kwiatkowska, Katarzyna, et al.
Publicado: (2014)

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts
por: Pipalia, Nina H., et al.
Publicado: (2021)

Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann–Pick C1 mutant cell via lysosome-associated membrane protein 1
por: Singhal, Ashutosh, et al.
Publicado: (2018)

Clinical disease characteristics of patients with Niemann-Pick Disease Type C: findings from the International Niemann-Pick Disease Registry (INPDR)
por: Bolton, Shaun C., et al.
Publicado: (2022)

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells
por: Maetzel, Dorothea, et al.
Publicado: (2014)

Clear Cell Chondrosarcoma in Association With Niemann-Pick Disease
por: Srikanth, K. N., et al.
Publicado: (2005)

Immune dysfunction in Niemann‐Pick disease type C
por: Platt, Nick, et al.
Publicado: (2015)

Anesthetic Management in a Child With Niemann-Pick Disease
por: Espahbodi, Ebrahim, et al.
Publicado: (2016)

Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder
por: Panigrahi, Inusha, et al.
Publicado: (2019)

A calcium message for Niemann-Pick type C
por: Cologna, Stephanie M.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_m567jftsb33iotm8n3251vbm1p