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Proposed Molecular and miRNA Classification of Gastric Cancer
Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause of cancer-related deaths. Despite some advances in therapies, long-term survival of patients with advanced disease remains poor. Different types of classification have been used to stratify patients with GC for sh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032377/ https://www.ncbi.nlm.nih.gov/pubmed/29882766 http://dx.doi.org/10.3390/ijms19061683 |
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author | Alessandrini, Lara Manchi, Melissa De Re, Valli Dolcetti, Riccardo Canzonieri, Vincenzo |
author_facet | Alessandrini, Lara Manchi, Melissa De Re, Valli Dolcetti, Riccardo Canzonieri, Vincenzo |
author_sort | Alessandrini, Lara |
collection | PubMed |
description | Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause of cancer-related deaths. Despite some advances in therapies, long-term survival of patients with advanced disease remains poor. Different types of classification have been used to stratify patients with GC for shaping prognosis and treatment planning. Based on new knowledge of molecular pathways associated with different aspect of GC, new pathogenetic classifications for GC have been and continue to be proposed. These novel classifications create a new paradigm in the definition of cancer biology and allow the identification of relevant GC genomic subsets by using different techniques such as genomic screenings, functional studies and molecular or epigenetic characterization. An improved prognostic classification for GC is essential for the development of a proper therapy for a proper patient population. The aim of this review is to discuss the state-of-the-art on combining histological and molecular classifications of GC to give an overview of the emerging therapeutic possibilities connected to the latest discoveries regarding GC. |
format | Online Article Text |
id | pubmed-6032377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60323772018-07-13 Proposed Molecular and miRNA Classification of Gastric Cancer Alessandrini, Lara Manchi, Melissa De Re, Valli Dolcetti, Riccardo Canzonieri, Vincenzo Int J Mol Sci Review Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause of cancer-related deaths. Despite some advances in therapies, long-term survival of patients with advanced disease remains poor. Different types of classification have been used to stratify patients with GC for shaping prognosis and treatment planning. Based on new knowledge of molecular pathways associated with different aspect of GC, new pathogenetic classifications for GC have been and continue to be proposed. These novel classifications create a new paradigm in the definition of cancer biology and allow the identification of relevant GC genomic subsets by using different techniques such as genomic screenings, functional studies and molecular or epigenetic characterization. An improved prognostic classification for GC is essential for the development of a proper therapy for a proper patient population. The aim of this review is to discuss the state-of-the-art on combining histological and molecular classifications of GC to give an overview of the emerging therapeutic possibilities connected to the latest discoveries regarding GC. MDPI 2018-06-06 /pmc/articles/PMC6032377/ /pubmed/29882766 http://dx.doi.org/10.3390/ijms19061683 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alessandrini, Lara Manchi, Melissa De Re, Valli Dolcetti, Riccardo Canzonieri, Vincenzo Proposed Molecular and miRNA Classification of Gastric Cancer |
title | Proposed Molecular and miRNA Classification of Gastric Cancer |
title_full | Proposed Molecular and miRNA Classification of Gastric Cancer |
title_fullStr | Proposed Molecular and miRNA Classification of Gastric Cancer |
title_full_unstemmed | Proposed Molecular and miRNA Classification of Gastric Cancer |
title_short | Proposed Molecular and miRNA Classification of Gastric Cancer |
title_sort | proposed molecular and mirna classification of gastric cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032377/ https://www.ncbi.nlm.nih.gov/pubmed/29882766 http://dx.doi.org/10.3390/ijms19061683 |
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