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Metabolomics in Plant Priming Research: The Way Forward?

A new era of plant biochemistry at the systems level is emerging, providing detailed descriptions of biochemical phenomena at the cellular and organismal level. This new era is marked by the advent of metabolomics—the qualitative and quantitative investigation of the entire metabolome (in a dynamic...

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Autores principales: Tugizimana, Fidele, Mhlongo, Msizi I., Piater, Lizelle A., Dubery, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032392/
https://www.ncbi.nlm.nih.gov/pubmed/29899301
http://dx.doi.org/10.3390/ijms19061759
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author Tugizimana, Fidele
Mhlongo, Msizi I.
Piater, Lizelle A.
Dubery, Ian A.
author_facet Tugizimana, Fidele
Mhlongo, Msizi I.
Piater, Lizelle A.
Dubery, Ian A.
author_sort Tugizimana, Fidele
collection PubMed
description A new era of plant biochemistry at the systems level is emerging, providing detailed descriptions of biochemical phenomena at the cellular and organismal level. This new era is marked by the advent of metabolomics—the qualitative and quantitative investigation of the entire metabolome (in a dynamic equilibrium) of a biological system. This field has developed as an indispensable methodological approach to study cellular biochemistry at a global level. For protection and survival in a constantly-changing environment, plants rely on a complex and multi-layered innate immune system. This involves surveillance of ‘self’ and ‘non-self,’ molecule-based systemic signalling and metabolic adaptations involving primary and secondary metabolites as well as epigenetic modulation mechanisms. Establishment of a pre-conditioned or primed state can sensitise or enhance aspects of innate immunity for faster and stronger responses. Comprehensive elucidation of the molecular and biochemical processes associated with the phenotypic defence state is vital for a better understanding of the molecular mechanisms that define the metabolism of plant–pathogen interactions. Such insights are essential for translational research and applications. Thus, this review highlights the prospects of metabolomics and addresses current challenges that hinder the realisation of the full potential of the field. Such limitations include partial coverage of the metabolome and maximising the value of metabolomics data (extraction of information and interpretation). Furthermore, the review points out key features that characterise both the plant innate immune system and enhancement of the latter, thus underlining insights from metabolomic studies in plant priming. Future perspectives in this inspiring area are included, with the aim of stimulating further studies leading to a better understanding of plant immunity at the metabolome level.
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spelling pubmed-60323922018-07-13 Metabolomics in Plant Priming Research: The Way Forward? Tugizimana, Fidele Mhlongo, Msizi I. Piater, Lizelle A. Dubery, Ian A. Int J Mol Sci Review A new era of plant biochemistry at the systems level is emerging, providing detailed descriptions of biochemical phenomena at the cellular and organismal level. This new era is marked by the advent of metabolomics—the qualitative and quantitative investigation of the entire metabolome (in a dynamic equilibrium) of a biological system. This field has developed as an indispensable methodological approach to study cellular biochemistry at a global level. For protection and survival in a constantly-changing environment, plants rely on a complex and multi-layered innate immune system. This involves surveillance of ‘self’ and ‘non-self,’ molecule-based systemic signalling and metabolic adaptations involving primary and secondary metabolites as well as epigenetic modulation mechanisms. Establishment of a pre-conditioned or primed state can sensitise or enhance aspects of innate immunity for faster and stronger responses. Comprehensive elucidation of the molecular and biochemical processes associated with the phenotypic defence state is vital for a better understanding of the molecular mechanisms that define the metabolism of plant–pathogen interactions. Such insights are essential for translational research and applications. Thus, this review highlights the prospects of metabolomics and addresses current challenges that hinder the realisation of the full potential of the field. Such limitations include partial coverage of the metabolome and maximising the value of metabolomics data (extraction of information and interpretation). Furthermore, the review points out key features that characterise both the plant innate immune system and enhancement of the latter, thus underlining insights from metabolomic studies in plant priming. Future perspectives in this inspiring area are included, with the aim of stimulating further studies leading to a better understanding of plant immunity at the metabolome level. MDPI 2018-06-13 /pmc/articles/PMC6032392/ /pubmed/29899301 http://dx.doi.org/10.3390/ijms19061759 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tugizimana, Fidele
Mhlongo, Msizi I.
Piater, Lizelle A.
Dubery, Ian A.
Metabolomics in Plant Priming Research: The Way Forward?
title Metabolomics in Plant Priming Research: The Way Forward?
title_full Metabolomics in Plant Priming Research: The Way Forward?
title_fullStr Metabolomics in Plant Priming Research: The Way Forward?
title_full_unstemmed Metabolomics in Plant Priming Research: The Way Forward?
title_short Metabolomics in Plant Priming Research: The Way Forward?
title_sort metabolomics in plant priming research: the way forward?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032392/
https://www.ncbi.nlm.nih.gov/pubmed/29899301
http://dx.doi.org/10.3390/ijms19061759
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