Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation

Leucine382 of cytochrome P450 1A2 (CYP1A2) plays an important role in binding and O-dealkylation of phenacetin, with the L382V mutation increasing substrate oxidation (Huang and Szklarz, 2010, Drug Metab. Dispos. 38:1039–1045). This was attributed to altered substrate binding orientation, but no dir...

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Detalles Bibliográficos
Autores principales: Huang, Qingbiao, Szklarz, Grazyna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032418/
https://www.ncbi.nlm.nih.gov/pubmed/29799514
http://dx.doi.org/10.3390/ijms19061580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032418/
https://www.ncbi.nlm.nih.gov/pubmed/29799514
http://dx.doi.org/10.3390/ijms19061580

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