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PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES

OBJECTIVE: It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). METHODS: Fifty-five patients were retrospectively evaluate...

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Autores principales: SANTOS, TELMA MURIAS DOS, ZUMÁRRAGA, JUAN PABLO, REAES, FÁBIO MAZETTI, MAÇANEIRO, CARLOS HENRIQUE, BAPTISTA, ANDRÉ MATHIAS, CAMARGO, OLAVO PIRES DE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ATHA EDITORA 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032620/
https://www.ncbi.nlm.nih.gov/pubmed/29983626
http://dx.doi.org/10.1590/1413-785220182602185549
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author SANTOS, TELMA MURIAS DOS
ZUMÁRRAGA, JUAN PABLO
REAES, FÁBIO MAZETTI
MAÇANEIRO, CARLOS HENRIQUE
BAPTISTA, ANDRÉ MATHIAS
CAMARGO, OLAVO PIRES DE
author_facet SANTOS, TELMA MURIAS DOS
ZUMÁRRAGA, JUAN PABLO
REAES, FÁBIO MAZETTI
MAÇANEIRO, CARLOS HENRIQUE
BAPTISTA, ANDRÉ MATHIAS
CAMARGO, OLAVO PIRES DE
author_sort SANTOS, TELMA MURIAS DOS
collection PubMed
description OBJECTIVE: It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). METHODS: Fifty-five patients were retrospectively evaluated, and forty-two were included (76.3%). RESULTS: Median age at diagnosis was 51.5 years, and median follow-up was 102.7 months. One patient had HIV. Pain in the affected site was the most prevalent symptom. The average time between symptom onset and diagnosis was 5.4 months. The vertebrae were most affected (n=16, 33.3%). According to the International Prognostic Index Score (IPI), 64.3% of the patients were classified as having low-grade lymphoma and 25.7% as low-intermediate. The most common histology was diffuse large B cell lymphoma (DLBCL) (85.7%). Immunophenotyping was CD20 positive in 93.5% of patients, and 11 patients had pathological fracture. All patients received chemotherapy and 30% of the regimens included rituximab. Thirty-eight percent of patients received radiation therapy. Overall survival was 50%, and survival median time was 80 months. Age and chemotherapy regimen influenced patient survival. Younger patients and patients who received RCHOP had better prognoses. CONCLUSIONS: The choice of chemotherapy regimen associated with age influenced survival for patients with PBL. Level of Evidence IV; Case series.
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spelling pubmed-60326202018-07-06 PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES SANTOS, TELMA MURIAS DOS ZUMÁRRAGA, JUAN PABLO REAES, FÁBIO MAZETTI MAÇANEIRO, CARLOS HENRIQUE BAPTISTA, ANDRÉ MATHIAS CAMARGO, OLAVO PIRES DE Acta Ortop Bras Original Articles OBJECTIVE: It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). METHODS: Fifty-five patients were retrospectively evaluated, and forty-two were included (76.3%). RESULTS: Median age at diagnosis was 51.5 years, and median follow-up was 102.7 months. One patient had HIV. Pain in the affected site was the most prevalent symptom. The average time between symptom onset and diagnosis was 5.4 months. The vertebrae were most affected (n=16, 33.3%). According to the International Prognostic Index Score (IPI), 64.3% of the patients were classified as having low-grade lymphoma and 25.7% as low-intermediate. The most common histology was diffuse large B cell lymphoma (DLBCL) (85.7%). Immunophenotyping was CD20 positive in 93.5% of patients, and 11 patients had pathological fracture. All patients received chemotherapy and 30% of the regimens included rituximab. Thirty-eight percent of patients received radiation therapy. Overall survival was 50%, and survival median time was 80 months. Age and chemotherapy regimen influenced patient survival. Younger patients and patients who received RCHOP had better prognoses. CONCLUSIONS: The choice of chemotherapy regimen associated with age influenced survival for patients with PBL. Level of Evidence IV; Case series. ATHA EDITORA 2018 /pmc/articles/PMC6032620/ /pubmed/29983626 http://dx.doi.org/10.1590/1413-785220182602185549 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Articles
SANTOS, TELMA MURIAS DOS
ZUMÁRRAGA, JUAN PABLO
REAES, FÁBIO MAZETTI
MAÇANEIRO, CARLOS HENRIQUE
BAPTISTA, ANDRÉ MATHIAS
CAMARGO, OLAVO PIRES DE
PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title_full PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title_fullStr PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title_full_unstemmed PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title_short PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
title_sort primary bone lymphomas: retrospective analysis of 42 consecutive cases
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032620/
https://www.ncbi.nlm.nih.gov/pubmed/29983626
http://dx.doi.org/10.1590/1413-785220182602185549
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