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Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol

BACKGROUND: Luteal support is a key to patients undergoing in vitro fertilization and embryo transfer (IVF-ET) with gonadotropin-releasing hormone (GnRH)-antagonist protocol. This study aimed to compare the effect between vaginal progesterone (VP) and intramuscular progesterone (IMP) with GnRH-antag...

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Autores principales: Chi, Hong-Bin, Liu, Na-Na, Li, Rong, Tao, Li-Yuan, Chen, Li-Xue, Qiao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032680/
https://www.ncbi.nlm.nih.gov/pubmed/29941709
http://dx.doi.org/10.4103/0366-6999.235106
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author Chi, Hong-Bin
Liu, Na-Na
Li, Rong
Tao, Li-Yuan
Chen, Li-Xue
Qiao, Jie
author_facet Chi, Hong-Bin
Liu, Na-Na
Li, Rong
Tao, Li-Yuan
Chen, Li-Xue
Qiao, Jie
author_sort Chi, Hong-Bin
collection PubMed
description BACKGROUND: Luteal support is a key to patients undergoing in vitro fertilization and embryo transfer (IVF-ET) with gonadotropin-releasing hormone (GnRH)-antagonist protocol. This study aimed to compare the effect between vaginal progesterone (VP) and intramuscular progesterone (IMP) with GnRH-antagonist protocol after IVF-ET. METHODS: A total of 1760 patients (18 years ≤ age ≤35 years) undergoing IVF-ET with GnRH-antagonist protocol were studied retrospectively between September 2014 and August 2015 in Peking University Third Hospital. In the patients, 1341 patients received VP (VP group) and 419 patients received IMP (IMP group) as luteal support. We compared clinical outcomes between these two groups. The primary objective of the study was the live birth rate. Measurement data between the two groups were conducted using independent samples t-test. The variables in line with non-normal distribution were expressed as median (p25 and p75) and were compared using nonparametric Mann–Whitney U-test. RESULTS: Live birth rate in VP group was 38.55%, significantly higher than that in the IMP group, which was 30.79% (χ(2) = 8.287, P = 0.004). The clinical intrauterine pregnancy rate and implantation rate in VP group were also significantly higher than those in the IMP group (clinical intrauterine pregnancy rate 47.35% vs. 41.29%, χ(2) = 4.727, P = 0.030; implantation rate 30.99% vs. 25.26%, χ(2) = 14.546, P < 0.001). Any statistically significant differences in ectopic pregnancy and abortion rates between two groups were not observed. CONCLUSION: Luteal support with VP had better clinical outcomes for young women undergoing IVF-ET with GnRH-antagonist protocol.
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spelling pubmed-60326802018-07-20 Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol Chi, Hong-Bin Liu, Na-Na Li, Rong Tao, Li-Yuan Chen, Li-Xue Qiao, Jie Chin Med J (Engl) Original Article BACKGROUND: Luteal support is a key to patients undergoing in vitro fertilization and embryo transfer (IVF-ET) with gonadotropin-releasing hormone (GnRH)-antagonist protocol. This study aimed to compare the effect between vaginal progesterone (VP) and intramuscular progesterone (IMP) with GnRH-antagonist protocol after IVF-ET. METHODS: A total of 1760 patients (18 years ≤ age ≤35 years) undergoing IVF-ET with GnRH-antagonist protocol were studied retrospectively between September 2014 and August 2015 in Peking University Third Hospital. In the patients, 1341 patients received VP (VP group) and 419 patients received IMP (IMP group) as luteal support. We compared clinical outcomes between these two groups. The primary objective of the study was the live birth rate. Measurement data between the two groups were conducted using independent samples t-test. The variables in line with non-normal distribution were expressed as median (p25 and p75) and were compared using nonparametric Mann–Whitney U-test. RESULTS: Live birth rate in VP group was 38.55%, significantly higher than that in the IMP group, which was 30.79% (χ(2) = 8.287, P = 0.004). The clinical intrauterine pregnancy rate and implantation rate in VP group were also significantly higher than those in the IMP group (clinical intrauterine pregnancy rate 47.35% vs. 41.29%, χ(2) = 4.727, P = 0.030; implantation rate 30.99% vs. 25.26%, χ(2) = 14.546, P < 0.001). Any statistically significant differences in ectopic pregnancy and abortion rates between two groups were not observed. CONCLUSION: Luteal support with VP had better clinical outcomes for young women undergoing IVF-ET with GnRH-antagonist protocol. Medknow Publications & Media Pvt Ltd 2018-07-05 /pmc/articles/PMC6032680/ /pubmed/29941709 http://dx.doi.org/10.4103/0366-6999.235106 Text en Copyright: © 2018 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chi, Hong-Bin
Liu, Na-Na
Li, Rong
Tao, Li-Yuan
Chen, Li-Xue
Qiao, Jie
Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title_full Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title_fullStr Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title_full_unstemmed Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title_short Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol
title_sort comparison of vaginal gel and intramuscular progesterone for in vitro fertilization and embryo transfer with gonadotropin-releasing hormone antagonist protocol
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032680/
https://www.ncbi.nlm.nih.gov/pubmed/29941709
http://dx.doi.org/10.4103/0366-6999.235106
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