Mbd2 enables tumourigenesis within the intestine while preventing tumour‐promoting inflammation

Epigenetic regulation plays a key role in the link between inflammation and cancer. Here we examine Mbd2, which mediates epigenetic transcriptional silencing by binding to methylated DNA. In separate studies the Mbd2 (−/−) mouse has been shown (1) to be resistant to intestinal tumourigenesis and (2)...

Descripción completa

Detalles Bibliográficos
Autores principales: May, Stephanie, Owen, Heather, Phesse, Toby J, Greenow, Kirsty R, Jones, Gareth‐Rhys, Blackwood, Adam, Cook, Peter C, Towers, Christopher, Gallimore, Awen M, Williams, Geraint T, Stürzl, Michael, Britzen‐Laurent, Nathalie, Sansom, Owen J, MacDonald, Andrew S, Bird, Adrian P, Clarke, Alan R, Parry, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032908/
https://www.ncbi.nlm.nih.gov/pubmed/29603746
http://dx.doi.org/10.1002/path.5074

Ejemplares similares

Ejemplares similares