Optogenetic Control of Voltage‐Gated Calcium Channels

Voltage‐gated Ca(2+) (Ca(V)) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca(V) channel modulators, to enable photo‐tunable modulation of Ca(V) ch...

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Detalles Bibliográficos
Autores principales: Ma, Guolin, Liu, Jindou, Ke, Yuepeng, Liu, Xin, Li, Minyong, Wang, Fen, Han, Gang, Huang, Yun, Wang, Youjun, Zhou, Yubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032918/
https://www.ncbi.nlm.nih.gov/pubmed/29569306
http://dx.doi.org/10.1002/anie.201713080
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author Ma, Guolin
Liu, Jindou
Ke, Yuepeng
Liu, Xin
Li, Minyong
Wang, Fen
Han, Gang
Huang, Yun
Wang, Youjun
Zhou, Yubin
author_facet Ma, Guolin
Liu, Jindou
Ke, Yuepeng
Liu, Xin
Li, Minyong
Wang, Fen
Han, Gang
Huang, Yun
Wang, Youjun
Zhou, Yubin
author_sort Ma, Guolin
collection PubMed
description Voltage‐gated Ca(2+) (Ca(V)) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca(V) channel modulators, to enable photo‐tunable modulation of Ca(V) channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for Ca(V) channels could find broad applications in interrogating a wide range of Ca(V)‐mediated physiological processes.
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spelling pubmed-60329182018-07-12 Optogenetic Control of Voltage‐Gated Calcium Channels Ma, Guolin Liu, Jindou Ke, Yuepeng Liu, Xin Li, Minyong Wang, Fen Han, Gang Huang, Yun Wang, Youjun Zhou, Yubin Angew Chem Int Ed Engl Communications Voltage‐gated Ca(2+) (Ca(V)) channels mediate Ca(2+) entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded Ca(V) channel modulators, to enable photo‐tunable modulation of Ca(V) channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for Ca(V) channels could find broad applications in interrogating a wide range of Ca(V)‐mediated physiological processes. John Wiley and Sons Inc. 2018-04-16 2018-06-11 /pmc/articles/PMC6032918/ /pubmed/29569306 http://dx.doi.org/10.1002/anie.201713080 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Ma, Guolin
Liu, Jindou
Ke, Yuepeng
Liu, Xin
Li, Minyong
Wang, Fen
Han, Gang
Huang, Yun
Wang, Youjun
Zhou, Yubin
Optogenetic Control of Voltage‐Gated Calcium Channels
title Optogenetic Control of Voltage‐Gated Calcium Channels
title_full Optogenetic Control of Voltage‐Gated Calcium Channels
title_fullStr Optogenetic Control of Voltage‐Gated Calcium Channels
title_full_unstemmed Optogenetic Control of Voltage‐Gated Calcium Channels
title_short Optogenetic Control of Voltage‐Gated Calcium Channels
title_sort optogenetic control of voltage‐gated calcium channels
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032918/
https://www.ncbi.nlm.nih.gov/pubmed/29569306
http://dx.doi.org/10.1002/anie.201713080
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