Cargando…
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle to late stages of tumourigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are n...
Autores principales: | Temko, Daniel, Van Gool, Inge C, Rayner, Emily, Glaire, Mark, Makino, Seiko, Brown, Matthew, Chegwidden, Laura, Palles, Claire, Depreeuw, Jeroen, Beggs, Andrew, Stathopoulou, Chaido, Mason, John, Baker, Ann‐Marie, Williams, Marc, Cerundolo, Vincenzo, Rei, Margarida, Taylor, Jenny C, Schuh, Anna, Ahmed, Ahmed, Amant, Frédéric, Lambrechts, Diether, Smit, Vincent THBM, Bosse, Tjalling, Graham, Trevor A, Church, David N, Tomlinson, Ian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032922/ https://www.ncbi.nlm.nih.gov/pubmed/29604063 http://dx.doi.org/10.1002/path.5081 |
Ejemplares similares
-
Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer
por: Church, David N., et al.
Publicado: (2014) -
POLE proofreading mutation, immune response and prognosis in endometrial cancer
por: van Gool, Inge C., et al.
Publicado: (2015) -
DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
por: Church, David N., et al.
Publicado: (2013) -
Mutation-Derived Neoantigens for Cancer Immunotherapy
por: Castle, John C., et al.
Publicado: (2019) -
Cancer neoantigens and immunogenicity: mutation position matters
por: Capietto, Aude-Hélène, et al.
Publicado: (2020)