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Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1

OBJECTIVE: Defective mitochondrial function attributed to optic atrophy 1 (OPA1) mutations causes primarily optic atrophy and, less commonly, neurodegenerative syndromes. The pathomechanism by which OPA1 mutations trigger diffuse loss of neurons in some, but not all, patients is unknown. Here, we us...

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Detalles Bibliográficos
Autores principales:	Jonikas, Mindaugas, Madill, Martin, Mathy, Alexandre, Zekoll, Theresa, Zois, Christos E., Wigfield, Simon, Kurzawa‐Akanbi, Marzena, Browne, Cathy, Sims, David, Chinnery, Patrick F., Cowley, Sally A., Tofaris, George K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032926/ https://www.ncbi.nlm.nih.gov/pubmed/29604226 http://dx.doi.org/10.1002/ana.25221

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