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Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C=C double bond in α,β‐unsaturated compounds bearing an electron‐withdrawing group, for example, a carbonyl group. This asymmetric reduction has been exploited for biocatalysis. Going beyond its canonical function, we show that member...

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Detalles Bibliográficos
Autores principales:	Heckenbichler, Kathrin, Schweiger, Anna, Brandner, Lea Alexandra, Binter, Alexandra, Toplak, Marina, Macheroux, Peter, Gruber, Karl, Breinbauer, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033016/ https://www.ncbi.nlm.nih.gov/pubmed/29689601 http://dx.doi.org/10.1002/anie.201802962

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