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The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease
BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD). OBJECTIVES: To test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD. METHODS: The RBDSQ was completed before vid...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033034/ https://www.ncbi.nlm.nih.gov/pubmed/30009211 http://dx.doi.org/10.1002/mdc3.12591 |
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author | Halsband, Claire Zapf, Antonia Sixel‐Döring, Friederike Trenkwalder, Claudia Mollenhauer, Brit |
author_facet | Halsband, Claire Zapf, Antonia Sixel‐Döring, Friederike Trenkwalder, Claudia Mollenhauer, Brit |
author_sort | Halsband, Claire |
collection | PubMed |
description | BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD). OBJECTIVES: To test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD. METHODS: The RBDSQ was completed before video‐supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG‐confirmed RBD diagnosis. RESULTS AND CONCLUSIONS: Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut‐off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56–0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut‐off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90–1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut‐off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63–0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed. |
format | Online Article Text |
id | pubmed-6033034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60330342018-07-12 The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease Halsband, Claire Zapf, Antonia Sixel‐Döring, Friederike Trenkwalder, Claudia Mollenhauer, Brit Mov Disord Clin Pract Research Articles BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the most specific prodromal indicators for Parkinson's disease (PD). OBJECTIVES: To test the validity of the RBD‐Screening Questionnaire (RBDSQ) in assessing RBD in early PD. METHODS: The RBDSQ was completed before video‐supported polysomnography (vPSG) by 134 de novo PD patients, 109 matched controls without neurological disorder (CTR) and 30 subjects with idiopathic RBD (iRBD) without clinical signs of PD; results were compared with vPSG‐confirmed RBD diagnosis. RESULTS AND CONCLUSIONS: Sensitivity/specificity of the RBDSQ for the PD cohort were 0.44/0.84 at the previously published cut‐off score of 6 for PD patients, and the area under the curve (AUC) 0.68 (95% CI, 0.56–0.79). By contrast, in the iRBD/CTR cohort the RBDSQ (cut‐off = 5) had a sensitivity/specificity of 0.97/0.84 and an AUC of 0.95 (95% CI, 0.90–1.00). Subanalysis of question 6 only (4 subitems asking for dream enactment) at a cut‐off score of 1 revealed a sensitivity of 0.74 and a specificity of 0.70 for the de novo PD cohort, AUC was 0.74 (95% CI, 0.63–0.84). RBDSQ is an insufficient screening tool for RBD in de novo PD. New screening tools for RBD assessment need to be developed. John Wiley and Sons Inc. 2018-03-01 /pmc/articles/PMC6033034/ /pubmed/30009211 http://dx.doi.org/10.1002/mdc3.12591 Text en © 2018 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Halsband, Claire Zapf, Antonia Sixel‐Döring, Friederike Trenkwalder, Claudia Mollenhauer, Brit The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title | The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title_full | The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title_fullStr | The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title_full_unstemmed | The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title_short | The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease |
title_sort | rem sleep behavior disorder screening questionnaire is not valid in de novo parkinson's disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033034/ https://www.ncbi.nlm.nih.gov/pubmed/30009211 http://dx.doi.org/10.1002/mdc3.12591 |
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