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A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment
Real‐world tolerability and effectiveness of nebivolol as first add‐on therapy were compared with hydrochlorothiazide, metoprolol, and amlodipine. Medical records of hypertensive adults initiating nebivolol, hydrochlorothiazide, metoprolol, or amlodipine as first add‐on therapy between December 16,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033036/ https://www.ncbi.nlm.nih.gov/pubmed/29902367 http://dx.doi.org/10.1111/jch.13312 |
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author | Ayyagari, Rajeev Xie, Jipan Cheng, David Wu, Eric Q. Huang, Xing‐Yue Chen, Stephanie |
author_facet | Ayyagari, Rajeev Xie, Jipan Cheng, David Wu, Eric Q. Huang, Xing‐Yue Chen, Stephanie |
author_sort | Ayyagari, Rajeev |
collection | PubMed |
description | Real‐world tolerability and effectiveness of nebivolol as first add‐on therapy were compared with hydrochlorothiazide, metoprolol, and amlodipine. Medical records of hypertensive adults initiating nebivolol, hydrochlorothiazide, metoprolol, or amlodipine as first add‐on therapy between December 16, 2010 and July 21, 2011 were retrospectively abstracted (N = 1600; 400/treatment). Outcomes included medication‐related side‐effect rates and blood pressure (BP) reduction and control. Compared with nebivolol, metoprolol and amlodipine had significantly higher side‐effect rates (incidence rate ratio [95% CI]: 1.82 [1.14‐2.92] and 2.67 [1.69‐4.21]), respectively); the hydrochlorothiazide‐nebivolol rate ratio was not significant (1.61 [0.95‐2.71]). All treatments reduced BP at 2 months. Metoprolol, amlodipine, and hydrochlorothiazide were associated with significantly lower odds of achieving 2‐month BP control than nebivolol (odds ratios [95% CI]: 0.34 [0.23‐0.51], 0.51 [0.35‐0.75] and 0.66 [0.44‐0.99], respectively). In a real‐world setting, nebivolol as first add‐on therapy was associated with fewer side effects than metoprolol or amlodipine and with a higher BP control rate than hydrochlorothiazide, metoprolol, or amlodipine. |
format | Online Article Text |
id | pubmed-6033036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60330362018-07-12 A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment Ayyagari, Rajeev Xie, Jipan Cheng, David Wu, Eric Q. Huang, Xing‐Yue Chen, Stephanie J Clin Hypertens (Greenwich) Hypertension Therapy Real‐world tolerability and effectiveness of nebivolol as first add‐on therapy were compared with hydrochlorothiazide, metoprolol, and amlodipine. Medical records of hypertensive adults initiating nebivolol, hydrochlorothiazide, metoprolol, or amlodipine as first add‐on therapy between December 16, 2010 and July 21, 2011 were retrospectively abstracted (N = 1600; 400/treatment). Outcomes included medication‐related side‐effect rates and blood pressure (BP) reduction and control. Compared with nebivolol, metoprolol and amlodipine had significantly higher side‐effect rates (incidence rate ratio [95% CI]: 1.82 [1.14‐2.92] and 2.67 [1.69‐4.21]), respectively); the hydrochlorothiazide‐nebivolol rate ratio was not significant (1.61 [0.95‐2.71]). All treatments reduced BP at 2 months. Metoprolol, amlodipine, and hydrochlorothiazide were associated with significantly lower odds of achieving 2‐month BP control than nebivolol (odds ratios [95% CI]: 0.34 [0.23‐0.51], 0.51 [0.35‐0.75] and 0.66 [0.44‐0.99], respectively). In a real‐world setting, nebivolol as first add‐on therapy was associated with fewer side effects than metoprolol or amlodipine and with a higher BP control rate than hydrochlorothiazide, metoprolol, or amlodipine. John Wiley and Sons Inc. 2018-06-13 /pmc/articles/PMC6033036/ /pubmed/29902367 http://dx.doi.org/10.1111/jch.13312 Text en © 2018 The Authors. The Journal of Clinical Hypertension Published by Wiley Periodicals, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Hypertension Therapy Ayyagari, Rajeev Xie, Jipan Cheng, David Wu, Eric Q. Huang, Xing‐Yue Chen, Stephanie A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title | A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title_full | A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title_fullStr | A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title_full_unstemmed | A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title_short | A retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
title_sort | retrospective study evaluating the tolerability and effectiveness of adjunctive antihypertensive drugs in patients with inadequate response to initial treatment |
topic | Hypertension Therapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033036/ https://www.ncbi.nlm.nih.gov/pubmed/29902367 http://dx.doi.org/10.1111/jch.13312 |
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