A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)

MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These imaging characteristics are advantageous for Dynamic Contrast Enhanced (DCE) imaging that can assess the combination of vascular flow and per...

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Autores principales: Hupple, Clinton W., Morscher, Stefan, Burton, Neal C., Pagel, Mark D., McNally, Lacey R., Cárdenas-Rodríguez, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033053/
https://www.ncbi.nlm.nih.gov/pubmed/29988890
http://dx.doi.org/10.1016/j.pacs.2018.04.003
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author Hupple, Clinton W.
Morscher, Stefan
Burton, Neal C.
Pagel, Mark D.
McNally, Lacey R.
Cárdenas-Rodríguez, Julio
author_facet Hupple, Clinton W.
Morscher, Stefan
Burton, Neal C.
Pagel, Mark D.
McNally, Lacey R.
Cárdenas-Rodríguez, Julio
author_sort Hupple, Clinton W.
collection PubMed
description MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These imaging characteristics are advantageous for Dynamic Contrast Enhanced (DCE) imaging that can assess the combination of vascular flow and permeability. However, the quantitative analysis of DCE MSOT data has not been possible due to complications caused by wavelength-dependent light attenuation and variability in light fluence at different anatomical locations. In this work we present a new method for the quantitative analysis of DCE MSOT data that is not biased by light fluence. We have named this method the two-compartment linear standard model (2C-LSM) for DCE MSOT.
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spelling pubmed-60330532018-07-09 A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT) Hupple, Clinton W. Morscher, Stefan Burton, Neal C. Pagel, Mark D. McNally, Lacey R. Cárdenas-Rodríguez, Julio Photoacoustics Research Article MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These imaging characteristics are advantageous for Dynamic Contrast Enhanced (DCE) imaging that can assess the combination of vascular flow and permeability. However, the quantitative analysis of DCE MSOT data has not been possible due to complications caused by wavelength-dependent light attenuation and variability in light fluence at different anatomical locations. In this work we present a new method for the quantitative analysis of DCE MSOT data that is not biased by light fluence. We have named this method the two-compartment linear standard model (2C-LSM) for DCE MSOT. Elsevier 2018-05-03 /pmc/articles/PMC6033053/ /pubmed/29988890 http://dx.doi.org/10.1016/j.pacs.2018.04.003 Text en © 2018 The Authors. Published by Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Hupple, Clinton W.
Morscher, Stefan
Burton, Neal C.
Pagel, Mark D.
McNally, Lacey R.
Cárdenas-Rodríguez, Julio
A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title_full A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title_fullStr A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title_full_unstemmed A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title_short A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)
title_sort light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (dce msot)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033053/
https://www.ncbi.nlm.nih.gov/pubmed/29988890
http://dx.doi.org/10.1016/j.pacs.2018.04.003
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