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Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study

INTRODUCTION: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between MYCN gene single-nucleotide polymorphisms (SNPs) and neurob...

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Autores principales: Zhou, Haixia, Zhuo, Zhenjian, Chen, Shanshan, Zhao, Jie, Mo, Yixiao, Zhang, Jiao, He, Jing, Ruan, Jichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033082/
https://www.ncbi.nlm.nih.gov/pubmed/29997440
http://dx.doi.org/10.2147/CMAR.S168515
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author Zhou, Haixia
Zhuo, Zhenjian
Chen, Shanshan
Zhao, Jie
Mo, Yixiao
Zhang, Jiao
He, Jing
Ruan, Jichen
author_facet Zhou, Haixia
Zhuo, Zhenjian
Chen, Shanshan
Zhao, Jie
Mo, Yixiao
Zhang, Jiao
He, Jing
Ruan, Jichen
author_sort Zhou, Haixia
collection PubMed
description INTRODUCTION: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between MYCN gene single-nucleotide polymorphisms (SNPs) and neuroblastoma risk. PATIENTS AND METHODS: To investigate the contribution of MYCN gene polymorphisms to neuroblastoma risk, we performed a 3-center case–control study by genotyping 4 SNPs in the MYCN gene from 429 cases and 884 controls. RESULTS: The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60–0.98, P=0.033), while the other 3 SNPs were not (rs9653226 T>C, rs13034994 A>G, and rs60226897 G>A). Stratified analysis revealed that rs57961569 GG carriers were more likely to develop neuroblastoma in the following subgroups: children older than 18 months, tumor derived from the adrenal gland, and clinical stages III + IV. The increased neuroblastoma risk associated with the rs9653226 variant CC genotypes was more evident in the following subgroups: females, tumor derived from the adrenal gland, and clinical stages III + IV. The presence of 2–3 risk genotypes had a significant relationship with the following subgroups: tumor derived from the adrenal gland and clinical stages III + IV. CONCLUSION: This study demonstrates a weak impact of MYCN gene polymorphisms on neuroblastoma risk, which should be further validated.
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spelling pubmed-60330822018-07-11 Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study Zhou, Haixia Zhuo, Zhenjian Chen, Shanshan Zhao, Jie Mo, Yixiao Zhang, Jiao He, Jing Ruan, Jichen Cancer Manag Res Original Research INTRODUCTION: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene is amplified in some neuroblastoma patients and correlated with poor prognosis. However, less is known regarding the relationship between MYCN gene single-nucleotide polymorphisms (SNPs) and neuroblastoma risk. PATIENTS AND METHODS: To investigate the contribution of MYCN gene polymorphisms to neuroblastoma risk, we performed a 3-center case–control study by genotyping 4 SNPs in the MYCN gene from 429 cases and 884 controls. RESULTS: The results showed that only rs57961569 G>A was associated with neuroblastoma risk (GA vs GG: adjusted odds ratio =0.76, 95% confidence interval =0.60–0.98, P=0.033), while the other 3 SNPs were not (rs9653226 T>C, rs13034994 A>G, and rs60226897 G>A). Stratified analysis revealed that rs57961569 GG carriers were more likely to develop neuroblastoma in the following subgroups: children older than 18 months, tumor derived from the adrenal gland, and clinical stages III + IV. The increased neuroblastoma risk associated with the rs9653226 variant CC genotypes was more evident in the following subgroups: females, tumor derived from the adrenal gland, and clinical stages III + IV. The presence of 2–3 risk genotypes had a significant relationship with the following subgroups: tumor derived from the adrenal gland and clinical stages III + IV. CONCLUSION: This study demonstrates a weak impact of MYCN gene polymorphisms on neuroblastoma risk, which should be further validated. Dove Medical Press 2018-07-02 /pmc/articles/PMC6033082/ /pubmed/29997440 http://dx.doi.org/10.2147/CMAR.S168515 Text en © 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhou, Haixia
Zhuo, Zhenjian
Chen, Shanshan
Zhao, Jie
Mo, Yixiao
Zhang, Jiao
He, Jing
Ruan, Jichen
Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title_full Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title_fullStr Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title_full_unstemmed Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title_short Polymorphisms in MYCN gene and neuroblastoma risk in Chinese children: a 3-center case–control study
title_sort polymorphisms in mycn gene and neuroblastoma risk in chinese children: a 3-center case–control study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033082/
https://www.ncbi.nlm.nih.gov/pubmed/29997440
http://dx.doi.org/10.2147/CMAR.S168515
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