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Comprehensive review of cardiovascular toxicity of drugs and related agents

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of dr...

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Autores principales: Mladěnka, Přemysl, Applová, Lenka, Patočka, Jiří, Costa, Vera Marisa, Remiao, Fernando, Pourová, Jana, Mladěnka, Aleš, Karlíčková, Jana, Jahodář, Luděk, Vopršalová, Marie, Varner, Kurt J., Štěrba, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033155/
https://www.ncbi.nlm.nih.gov/pubmed/29315692
http://dx.doi.org/10.1002/med.21476
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author Mladěnka, Přemysl
Applová, Lenka
Patočka, Jiří
Costa, Vera Marisa
Remiao, Fernando
Pourová, Jana
Mladěnka, Aleš
Karlíčková, Jana
Jahodář, Luděk
Vopršalová, Marie
Varner, Kurt J.
Štěrba, Martin
author_facet Mladěnka, Přemysl
Applová, Lenka
Patočka, Jiří
Costa, Vera Marisa
Remiao, Fernando
Pourová, Jana
Mladěnka, Aleš
Karlíčková, Jana
Jahodář, Luděk
Vopršalová, Marie
Varner, Kurt J.
Štěrba, Martin
author_sort Mladěnka, Přemysl
collection PubMed
description Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway.
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spelling pubmed-60331552018-07-12 Comprehensive review of cardiovascular toxicity of drugs and related agents Mladěnka, Přemysl Applová, Lenka Patočka, Jiří Costa, Vera Marisa Remiao, Fernando Pourová, Jana Mladěnka, Aleš Karlíčková, Jana Jahodář, Luděk Vopršalová, Marie Varner, Kurt J. Štěrba, Martin Med Res Rev Review Articles Cardiovascular diseases are a leading cause of morbidity and mortality in most developed countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to the overall cardiovascular burden and thus deserve attention. The present article is a systematic overview of drugs that may induce distinct cardiovascular toxicity. The compounds are classified into agents that have significant effects on the heart, blood vessels, or both. The mechanism(s) of toxic action are discussed and treatment modalities are briefly mentioned in relevant cases. Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. Particular emphasis is given to clinically relevant topics including the cardiovascular toxicity of illicit sympathomimetic drugs (e.g., cocaine, amphetamines, cathinones), drugs that prolong the QT interval, antidysrhythmic drugs, digoxin and other cardioactive steroids, beta‐blockers, calcium channel blockers, female hormones, nonsteroidal anti‐inflammatory, and anticancer compounds encompassing anthracyclines and novel targeted therapy interfering with the HER2 or the vascular endothelial growth factor pathway. John Wiley and Sons Inc. 2018-01-05 2018-07 /pmc/articles/PMC6033155/ /pubmed/29315692 http://dx.doi.org/10.1002/med.21476 Text en © 2018 The Authors Medicinal Research Reviews Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Mladěnka, Přemysl
Applová, Lenka
Patočka, Jiří
Costa, Vera Marisa
Remiao, Fernando
Pourová, Jana
Mladěnka, Aleš
Karlíčková, Jana
Jahodář, Luděk
Vopršalová, Marie
Varner, Kurt J.
Štěrba, Martin
Comprehensive review of cardiovascular toxicity of drugs and related agents
title Comprehensive review of cardiovascular toxicity of drugs and related agents
title_full Comprehensive review of cardiovascular toxicity of drugs and related agents
title_fullStr Comprehensive review of cardiovascular toxicity of drugs and related agents
title_full_unstemmed Comprehensive review of cardiovascular toxicity of drugs and related agents
title_short Comprehensive review of cardiovascular toxicity of drugs and related agents
title_sort comprehensive review of cardiovascular toxicity of drugs and related agents
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033155/
https://www.ncbi.nlm.nih.gov/pubmed/29315692
http://dx.doi.org/10.1002/med.21476
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