DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis

BACKGROUND: The mammalian target of rapamycin (mTOR) pathway plays a significant role in osteogenic differentiation and bone maintenance. As the only known endogenous inhibitor of mTOR function, DEP domain containing mTOR interacting protein (DEPTOR) is potentially involved in stem cell differentiat...

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Detalles Bibliográficos
Autores principales: Chen, Si, Jia, Lingfei, Zhang, Shan, Zheng, Yunfei, Zhou, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033203/
https://www.ncbi.nlm.nih.gov/pubmed/29973283
http://dx.doi.org/10.1186/s13287-018-0935-9

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