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Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

BACKGROUND: Iron accumulation in basal ganglia accompanies neuronal loss in Huntington’s disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. Therefore, investigating the mechanism of iron accumulation is essential to unde...

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Detalles Bibliográficos
Autores principales:	Niu, Li, Ye, Cuifang, Sun, Yun, Peng, Ting, Yang, Shiming, Wang, Weixi, Li, He
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033216/ https://www.ncbi.nlm.nih.gov/pubmed/30002810 http://dx.doi.org/10.1186/s13578-018-0239-x

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