RIOK1 kinase activity is required for cell survival irrespective of MTAP status

Genotype specific vulnerabilities of cancer cells constitute a promising strategy for the development of new therapeutics. Deletions of non-essential genes in tumors can generate unique vulnerabilities which could be exploited therapeutically. The MTAP gene is recurrently deleted in human cancers be...

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Detalles Bibliográficos
Autores principales: Hörmann, Alexandra, Hopfgartner, Barbara, Köcher, Thomas, Corcokovic, Maja, Krammer, Teresa, Reiser, Christoph, Bader, Gerd, Shi, Junwei, Ehrenhöfer, Katharina, Wöhrle, Simon, Schweifer, Norbert, Vakoc, Christopher R., Kraut, Norbert, Pearson, Mark, Petronczki, Mark, Neumüller, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033344/
https://www.ncbi.nlm.nih.gov/pubmed/29983885
http://dx.doi.org/10.18632/oncotarget.25586

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