Simultaneous delivery of olaparib and carboplatin in PEGylated liposomes imparts this drug combination hypersensitivity and selectivity for breast tumor cells

Combination regiments involving platinum anticancer drugs and agents with unrelated mechanisms of action are a subject of widespread interest. Here, we show that synergistic toxic action in cancer cells of combinations of antitumor platinum drug carboplatin and effective PARP inhibitor olaparib is c...

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Detalles Bibliográficos
Autores principales: Novohradsky, Vojtech, Zajac, Juraj, Vrana, Oldrich, Kasparkova, Jana, Brabec, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033346/
https://www.ncbi.nlm.nih.gov/pubmed/29983873
http://dx.doi.org/10.18632/oncotarget.25466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033346/
https://www.ncbi.nlm.nih.gov/pubmed/29983873
http://dx.doi.org/10.18632/oncotarget.25466

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