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P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer

Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human...

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Detalles Bibliográficos
Autores principales:	Barrio-Real, Laura, Lopez-Haber, Cynthia, Casado-Medrano, Victoria, Goglia, Alexander G., Toettcher, Jared E., Caloca, Maria J., Kazanietz, Marcelo G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033363/ https://www.ncbi.nlm.nih.gov/pubmed/29983884 http://dx.doi.org/10.18632/oncotarget.25584

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