PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

BACKGROUND: Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CA(mut)) in GBM are restricted to three functional domains: adaptor binding (ABD), helical, and kinase. Defining how these...

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Detalles Bibliográficos
Autores principales: McNeill, Robert S., Stroobant, Emily E., Smithberger, Erin, Canoutas, Demitra A., Butler, Madison K., Shelton, Abigail K., Patel, Shrey D., Limas, Juanita C., Skinner, Kasey R., Bash, Ryan E., Schmid, Ralf S., Miller, C. Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033446/
https://www.ncbi.nlm.nih.gov/pubmed/29975751
http://dx.doi.org/10.1371/journal.pone.0200014

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