Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach

Apolipoprotein E (apoE) is a forefront actor in the transport of lipids and the maintenance of cholesterol homeostasis, and is also strongly implicated in Alzheimer’s disease. Upon lipid-binding apoE adopts a conformational state that mediates the receptor-induced internalization of lipoproteins. Du...

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Detalles Bibliográficos
Autores principales: Henry, Nicolas, Krammer, Eva-Maria, Stengel, Florian, Adams, Quentin, Van Liefferinge, François, Hubin, Ellen, Chaves, Rui, Efremov, Rouslan, Aebersold, Ruedi, Vandenbussche, Guy, Prévost, Martine, Raussens, Vincent, Deroo, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033463/
https://www.ncbi.nlm.nih.gov/pubmed/29933361
http://dx.doi.org/10.1371/journal.pcbi.1006165

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