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ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex

Cellular responses to low oxygen conditions are mainly regulated by the Hypoxia-inducible factors (HIFs). Induction of HIF-1α in tumor cells activates the angiogenic switch and allows for metabolic adaptations. HIF-1α protein levels are tightly regulated through ubiquitin-mediated proteosomal degrad...

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Detalles Bibliográficos
Autores principales:	Stantic, Marina, Wolfsberger, Johanna, Sakil, Habib A. M., Wilhelm, Margareta T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033838/ https://www.ncbi.nlm.nih.gov/pubmed/29628507 http://dx.doi.org/10.1038/s41388-018-0195-2

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