Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration

Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute pe...

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Autores principales: Volpi, Vera Giulia, Pagani, Isabel, Ghezzi, Silvia, Iannacone, Matteo, D’Antonio, Maurizio, Vicenzi, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033858/
https://www.ncbi.nlm.nih.gov/pubmed/29976926
http://dx.doi.org/10.1038/s41598-018-28257-5
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author Volpi, Vera Giulia
Pagani, Isabel
Ghezzi, Silvia
Iannacone, Matteo
D’Antonio, Maurizio
Vicenzi, Elisa
author_facet Volpi, Vera Giulia
Pagani, Isabel
Ghezzi, Silvia
Iannacone, Matteo
D’Antonio, Maurizio
Vicenzi, Elisa
author_sort Volpi, Vera Giulia
collection PubMed
description Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity.
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spelling pubmed-60338582018-07-12 Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration Volpi, Vera Giulia Pagani, Isabel Ghezzi, Silvia Iannacone, Matteo D’Antonio, Maurizio Vicenzi, Elisa Sci Rep Article Zika virus (ZIKV) is a neurotropic agent that targets the developing fetal brain in women infected during pregnancy. In addition to the developing central nervous system, ZIKV has been recently shown to infect cells of the peripheral nervous system (PNS), highlighting its potential to cause acute peripheral neuropathies in adults, such as Guillain-Barré Syndrome (GBS). Here we show that myelinating dorsal root ganglia (DRG) explants obtained from interferon-alpha/beta receptor knock-out mice are productively infected by ZIKV. Virus replication is cytopathic in both peripheral neurons and myelinating Schwann cells leading to myelin disruption. These results confirm and extend previous observations suggesting that the PNS is indeed a potential site of ZIKV infection, replication and cytopathicity. Nature Publishing Group UK 2018-07-05 /pmc/articles/PMC6033858/ /pubmed/29976926 http://dx.doi.org/10.1038/s41598-018-28257-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Volpi, Vera Giulia
Pagani, Isabel
Ghezzi, Silvia
Iannacone, Matteo
D’Antonio, Maurizio
Vicenzi, Elisa
Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title_full Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title_fullStr Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title_full_unstemmed Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title_short Zika Virus Replication in Dorsal Root Ganglia Explants from Interferon Receptor1 Knockout Mice Causes Myelin Degeneration
title_sort zika virus replication in dorsal root ganglia explants from interferon receptor1 knockout mice causes myelin degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033858/
https://www.ncbi.nlm.nih.gov/pubmed/29976926
http://dx.doi.org/10.1038/s41598-018-28257-5
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