Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector

Long-lived latently HIV-1-infected cells represent a barrier to cure. We developed a dual-fluorescence HIV-1-based vector containing a pair of genetic insulators flanking a constitutive fluorescent reporter gene to study HIV-1 latency. The protective effects of these genetic insulators are demonstra...

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Detalles Bibliográficos
Autores principales: Kok, Yik Lim, Schmutz, Stefan, Inderbitzin, Anne, Neumann, Kathrin, Kelley, Audrey, Jörimann, Lisa, Shilaih, Mohaned, Vongrad, Valentina, Kouyos, Roger D., Günthard, Huldrych F., Berens, Christian, Metzner, Karin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033903/
https://www.ncbi.nlm.nih.gov/pubmed/29977044
http://dx.doi.org/10.1038/s41598-018-28161-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033903/
https://www.ncbi.nlm.nih.gov/pubmed/29977044
http://dx.doi.org/10.1038/s41598-018-28161-y

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