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A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems

Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host–guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantio...

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Autores principales: Sun, Yue, Zhang, Fan, Quan, Jiaxin, Zhu, Fei, Hong, Wei, Ma, Junkai, Pang, Huan, Sun, Yao, Tian, Demei, Li, Haibing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033921/
https://www.ncbi.nlm.nih.gov/pubmed/29976986
http://dx.doi.org/10.1038/s41467-018-05103-w
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author Sun, Yue
Zhang, Fan
Quan, Jiaxin
Zhu, Fei
Hong, Wei
Ma, Junkai
Pang, Huan
Sun, Yao
Tian, Demei
Li, Haibing
author_facet Sun, Yue
Zhang, Fan
Quan, Jiaxin
Zhu, Fei
Hong, Wei
Ma, Junkai
Pang, Huan
Sun, Yao
Tian, Demei
Li, Haibing
author_sort Sun, Yue
collection PubMed
description Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host–guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantiomers and can be switched “off” by d-glucose and be switched “on” by l-glucose. Remarkably, the chiral nanochannel also exhibited a good reversibility toward glucose enantiomers. Further research indicates that the switching behaviors differed due to the differences in binding strength between chiral pillar[6]arene and glucose enantiomers, which can lead to the different surface charge within nanochannel. Given these promising results, the studies of chiral-driven ion gates may not only give interesting insight for the research of biological and pathological processes caused by glucose-sensitive ion channels, but also help to understand the origin of the high stereoselectivity in life systems.
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spelling pubmed-60339212018-07-09 A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems Sun, Yue Zhang, Fan Quan, Jiaxin Zhu, Fei Hong, Wei Ma, Junkai Pang, Huan Sun, Yao Tian, Demei Li, Haibing Nat Commun Article Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host–guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantiomers and can be switched “off” by d-glucose and be switched “on” by l-glucose. Remarkably, the chiral nanochannel also exhibited a good reversibility toward glucose enantiomers. Further research indicates that the switching behaviors differed due to the differences in binding strength between chiral pillar[6]arene and glucose enantiomers, which can lead to the different surface charge within nanochannel. Given these promising results, the studies of chiral-driven ion gates may not only give interesting insight for the research of biological and pathological processes caused by glucose-sensitive ion channels, but also help to understand the origin of the high stereoselectivity in life systems. Nature Publishing Group UK 2018-07-05 /pmc/articles/PMC6033921/ /pubmed/29976986 http://dx.doi.org/10.1038/s41467-018-05103-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sun, Yue
Zhang, Fan
Quan, Jiaxin
Zhu, Fei
Hong, Wei
Ma, Junkai
Pang, Huan
Sun, Yao
Tian, Demei
Li, Haibing
A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title_full A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title_fullStr A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title_full_unstemmed A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title_short A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
title_sort biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033921/
https://www.ncbi.nlm.nih.gov/pubmed/29976986
http://dx.doi.org/10.1038/s41467-018-05103-w
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