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Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and isolation of antigen-specific T-cells but recent evidence shows that normal use of these reagents can miss fully functional T-cells that bear T-cell receptors (TCRs) with low affinity for cognate antigen. This issue i...

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Detalles Bibliográficos
Autores principales:	Dolton, Garry, Zervoudi, Efthalia, Rius, Cristina, Wall, Aaron, Thomas, Hannah L., Fuller, Anna, Yeo, Lorraine, Legut, Mateusz, Wheeler, Sophie, Attaf, Meriem, Chudakov, Dmitriy M., Choy, Ernest, Peakman, Mark, Sewell, Andrew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034003/ https://www.ncbi.nlm.nih.gov/pubmed/30008714 http://dx.doi.org/10.3389/fimmu.2018.01378

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