Effect of a cathepsin K inhibitor on arthritis and bone mineral density in ovariectomized rats with collagen-induced arthritis

OBJECTIVES: Cathepsin K is expressed by osteoclasts and synovial fibroblasts and degrades key components of bone and cartilage. Inhibition of cathepsin K protease activity may be beneficial for the prevention of bone erosion and cartilage degradation in rheumatoid arthritis (RA). The collagen-induce...

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Detalles Bibliográficos
Autores principales: Yamashita, Takahiro, Hagino, Hiroshi, Hayashi, Ikuta, Hayashibara, Masako, Tanida, Atsushi, Nagira, Keita, Fukui, Ryohei, Nagashima, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034140/
https://www.ncbi.nlm.nih.gov/pubmed/29992179
http://dx.doi.org/10.1016/j.bonr.2018.05.006

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