The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites

The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy i...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Reilly, Jessica, Pangilinan, Faith, Hokamp, Karsten, Ueland, Per M., Brosnan, John T., Brosnan, Margaret E., Brody, Lawrence C., Molloy, Anne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034155/
https://www.ncbi.nlm.nih.gov/pubmed/29988937
http://dx.doi.org/10.1016/j.ymgmr.2018.05.006
Descripción
Sumario:The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy individuals. Fifty-two variants tagging (r(2) < 0.9) the four GCS genes were tested; one variant, GLDC rs2297442-G, was significantly associated (p = .0007) with decreased glycine concentrations in serum.

Ejemplares similares