The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites

The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy i...

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Autores principales: O'Reilly, Jessica, Pangilinan, Faith, Hokamp, Karsten, Ueland, Per M., Brosnan, John T., Brosnan, Margaret E., Brody, Lawrence C., Molloy, Anne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034155/
https://www.ncbi.nlm.nih.gov/pubmed/29988937
http://dx.doi.org/10.1016/j.ymgmr.2018.05.006
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author O'Reilly, Jessica
Pangilinan, Faith
Hokamp, Karsten
Ueland, Per M.
Brosnan, John T.
Brosnan, Margaret E.
Brody, Lawrence C.
Molloy, Anne M.
author_facet O'Reilly, Jessica
Pangilinan, Faith
Hokamp, Karsten
Ueland, Per M.
Brosnan, John T.
Brosnan, Margaret E.
Brody, Lawrence C.
Molloy, Anne M.
author_sort O'Reilly, Jessica
collection PubMed
description The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy individuals. Fifty-two variants tagging (r(2) < 0.9) the four GCS genes were tested; one variant, GLDC rs2297442-G, was significantly associated (p = .0007) with decreased glycine concentrations in serum.
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spelling pubmed-60341552018-07-09 The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites O'Reilly, Jessica Pangilinan, Faith Hokamp, Karsten Ueland, Per M. Brosnan, John T. Brosnan, Margaret E. Brody, Lawrence C. Molloy, Anne M. Mol Genet Metab Rep Short Communication The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy individuals. Fifty-two variants tagging (r(2) < 0.9) the four GCS genes were tested; one variant, GLDC rs2297442-G, was significantly associated (p = .0007) with decreased glycine concentrations in serum. Elsevier 2018-06-11 /pmc/articles/PMC6034155/ /pubmed/29988937 http://dx.doi.org/10.1016/j.ymgmr.2018.05.006 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
O'Reilly, Jessica
Pangilinan, Faith
Hokamp, Karsten
Ueland, Per M.
Brosnan, John T.
Brosnan, Margaret E.
Brody, Lawrence C.
Molloy, Anne M.
The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title_full The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title_fullStr The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title_full_unstemmed The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title_short The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
title_sort impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034155/
https://www.ncbi.nlm.nih.gov/pubmed/29988937
http://dx.doi.org/10.1016/j.ymgmr.2018.05.006
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