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Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude

High altitude (HA) exposure may affect human health and performance by involving the body timing system. Daily variations of melatonin may disrupt by HA exposure, thereby possibly affecting its relations with a metabolic parameter like the respiratory quotient (RQ). Sea level (SL) volunteers (7 wome...

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Autores principales: Tapia, Marcelo, Wulff-Zottele, Cristian, De Gregorio, Nicole, Lang, Morin, Varela, Héctor, Josefa Serón-Ferré, María, Vivaldi, Ennio A., Araneda, Oscar F., Silva-Urra, Juan, Gunga, Hanns-Christian, Behn, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034204/
https://www.ncbi.nlm.nih.gov/pubmed/30008674
http://dx.doi.org/10.3389/fphys.2018.00798
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author Tapia, Marcelo
Wulff-Zottele, Cristian
De Gregorio, Nicole
Lang, Morin
Varela, Héctor
Josefa Serón-Ferré, María
Vivaldi, Ennio A.
Araneda, Oscar F.
Silva-Urra, Juan
Gunga, Hanns-Christian
Behn, Claus
author_facet Tapia, Marcelo
Wulff-Zottele, Cristian
De Gregorio, Nicole
Lang, Morin
Varela, Héctor
Josefa Serón-Ferré, María
Vivaldi, Ennio A.
Araneda, Oscar F.
Silva-Urra, Juan
Gunga, Hanns-Christian
Behn, Claus
author_sort Tapia, Marcelo
collection PubMed
description High altitude (HA) exposure may affect human health and performance by involving the body timing system. Daily variations of melatonin may disrupt by HA exposure, thereby possibly affecting its relations with a metabolic parameter like the respiratory quotient (RQ). Sea level (SL) volunteers (7 women and 7 men, 21.0 ± 2.04 y) were examined for daily changes in salivary melatonin concentration (SMC). Sampling was successively done at SL (Antofagasta, Chile) and, on acute HA exposure, at nearby Caspana (3,270 m asl). Saliva was collected in special vials (Salimetrics Oral Swab, United Kingdom) at sunny noon (SMC(D)) and in the absence of blue light at midnight (SMC(N)). The samples were obtained after rinsing the mouth with tap water and were analyzed for SMC by immunoassay (ELISA kit; IBL International, Germany). RQ measurements (n = 12) were realized with a portable breath to breath metabolic system (Oxicon(TM) Mobile, Germany), between 8:00 PM and 10:00 PM, once at either location. At SL, SMC(D), and SMC(N) values (mean ± SD) were, respectively, 2.14 ± 1.30 and 11.6 ± 13.9 pg/ml (p < 0.05). Corresponding values at HA were 8.83 ± 12.6 and 13.7 ± 16.7 pg/ml (n.s.). RQ was 0.78 ± 0.07 and 0.89 ± 0.08, respectively, at SL and HA (p < 0.05). Differences between SMC(N) and SMC(D) (SMC(N)–SMC(D)) strongly correlate with the corresponding RQ values at SL (r = -0.74) and less tight at HA (r = -0.37). Similarly, mean daily SMC values (SMC([Image: see text])) tightly correlate with RQ at SL (r = -0.79) and weaker at HA (r = -0.31). SMC(N)–SMC(D), as well as, SMC([Image: see text]) values at SL, on the other hand, respectively, correlate with the corresponding values at HA (r = 0.71 and r = 0.85). Acute exposure to HA appears to loosen relations of SMC with RQ. A personal profile in daily SMC variation, on the other hand, tends to be conserved at HA.
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spelling pubmed-60342042018-07-13 Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude Tapia, Marcelo Wulff-Zottele, Cristian De Gregorio, Nicole Lang, Morin Varela, Héctor Josefa Serón-Ferré, María Vivaldi, Ennio A. Araneda, Oscar F. Silva-Urra, Juan Gunga, Hanns-Christian Behn, Claus Front Physiol Physiology High altitude (HA) exposure may affect human health and performance by involving the body timing system. Daily variations of melatonin may disrupt by HA exposure, thereby possibly affecting its relations with a metabolic parameter like the respiratory quotient (RQ). Sea level (SL) volunteers (7 women and 7 men, 21.0 ± 2.04 y) were examined for daily changes in salivary melatonin concentration (SMC). Sampling was successively done at SL (Antofagasta, Chile) and, on acute HA exposure, at nearby Caspana (3,270 m asl). Saliva was collected in special vials (Salimetrics Oral Swab, United Kingdom) at sunny noon (SMC(D)) and in the absence of blue light at midnight (SMC(N)). The samples were obtained after rinsing the mouth with tap water and were analyzed for SMC by immunoassay (ELISA kit; IBL International, Germany). RQ measurements (n = 12) were realized with a portable breath to breath metabolic system (Oxicon(TM) Mobile, Germany), between 8:00 PM and 10:00 PM, once at either location. At SL, SMC(D), and SMC(N) values (mean ± SD) were, respectively, 2.14 ± 1.30 and 11.6 ± 13.9 pg/ml (p < 0.05). Corresponding values at HA were 8.83 ± 12.6 and 13.7 ± 16.7 pg/ml (n.s.). RQ was 0.78 ± 0.07 and 0.89 ± 0.08, respectively, at SL and HA (p < 0.05). Differences between SMC(N) and SMC(D) (SMC(N)–SMC(D)) strongly correlate with the corresponding RQ values at SL (r = -0.74) and less tight at HA (r = -0.37). Similarly, mean daily SMC values (SMC([Image: see text])) tightly correlate with RQ at SL (r = -0.79) and weaker at HA (r = -0.31). SMC(N)–SMC(D), as well as, SMC([Image: see text]) values at SL, on the other hand, respectively, correlate with the corresponding values at HA (r = 0.71 and r = 0.85). Acute exposure to HA appears to loosen relations of SMC with RQ. A personal profile in daily SMC variation, on the other hand, tends to be conserved at HA. Frontiers Media S.A. 2018-06-29 /pmc/articles/PMC6034204/ /pubmed/30008674 http://dx.doi.org/10.3389/fphys.2018.00798 Text en Copyright © 2018 Tapia, Wulff-Zottele, De Gregorio, Lang, Varela, Serón-Ferré, Vivaldi, Araneda, Silva-Urra, Gunga and Behn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tapia, Marcelo
Wulff-Zottele, Cristian
De Gregorio, Nicole
Lang, Morin
Varela, Héctor
Josefa Serón-Ferré, María
Vivaldi, Ennio A.
Araneda, Oscar F.
Silva-Urra, Juan
Gunga, Hanns-Christian
Behn, Claus
Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title_full Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title_fullStr Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title_full_unstemmed Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title_short Melatonin Relations With Respiratory Quotient Weaken on Acute Exposure to High Altitude
title_sort melatonin relations with respiratory quotient weaken on acute exposure to high altitude
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034204/
https://www.ncbi.nlm.nih.gov/pubmed/30008674
http://dx.doi.org/10.3389/fphys.2018.00798
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