Potent O-antigen-deficient (rough) mutants of Salmonella Typhimurium secreting Lawsonia intracellularis antigens enhance immunogenicity and provide single-immunization protection against proliferative enteropathy and salmonellosis in a murine model

The obligate intracellular pathogen Lawsonia intracellularis (LI), the etiological agent of proliferative enteropathy (PE), poses a substantial economic loss in the swine industry worldwide. In this study, we genetically engineered an O-antigen-deficient (rough) Salmonella strain secreting four sele...

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Detalles Bibliográficos
Autores principales: Park, Suyeon, Won, Gayeon, Kim, Jehyoung, Kim, Hyeun Bum, Lee, John Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034208/
https://www.ncbi.nlm.nih.gov/pubmed/29976253
http://dx.doi.org/10.1186/s13567-018-0552-8

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