The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms

BACKGROUND: The epidermal growth factor receptor (EGFR) is closely implicated in cancer, and sequencing analyses have revealed a high mutation rate of EGFR in lung cancer. Recent advances have provided novel insights into the endocytic regulation of wild-type EGFR, but that of mutated EGFR remains e...

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Detalles Bibliográficos
Autores principales: Wang, Taishu, Zhang, Jinrui, Wang, Shanshan, Sun, Xiuna, Wang, Duchuang, Gao, Yurou, Zhang, Yang, Xu, Lu, Wu, Yue, Wu, Yueguang, Liu, Fang, Liu, Xiuxiu, Liu, Shuyan, Zhang, Yingqiu, Wang, Yang, Zou, Lijuan, Liu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034242/
https://www.ncbi.nlm.nih.gov/pubmed/29976202
http://dx.doi.org/10.1186/s12964-018-0245-y

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