Cargando…

Youth at-risk for serious mental illness: methods of the PROCAN study

BACKGROUND: Most mental disorders begin in adolescence; however, there are gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop a mental i...

Descripción completa

Detalles Bibliográficos
Autores principales: Addington, Jean, Goldstein, Benjamin I., Wang, Jian Li, Kennedy, Sidney H., Bray, Signe, Lebel, Catherine, Hassel, Stefanie, Marshall, Catherine, MacQueen, Glenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034268/
https://www.ncbi.nlm.nih.gov/pubmed/29976184
http://dx.doi.org/10.1186/s12888-018-1801-0
_version_ 1783337844985561088
author Addington, Jean
Goldstein, Benjamin I.
Wang, Jian Li
Kennedy, Sidney H.
Bray, Signe
Lebel, Catherine
Hassel, Stefanie
Marshall, Catherine
MacQueen, Glenda
author_facet Addington, Jean
Goldstein, Benjamin I.
Wang, Jian Li
Kennedy, Sidney H.
Bray, Signe
Lebel, Catherine
Hassel, Stefanie
Marshall, Catherine
MacQueen, Glenda
author_sort Addington, Jean
collection PubMed
description BACKGROUND: Most mental disorders begin in adolescence; however, there are gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop a mental illness, what that illness will be, and what can be done to change its course and prevent its worsening to a serious mental illness (SMI). There are also gaps in our understanding of how known risk factors set off neurobiological changes that may play a role in determining who will develop a SMI. Project goals are (i) to identify youth at different stages of risk of SMI so that intervention can begin as soon as possible and (ii) to understand the triggers of these mental illnesses. METHOD: This 2-site longitudinal study will recruit 240 youth, ages 12–25, who are at different stages of risk for developing a SMI. The sample includes (a) healthy individuals, (b) symptom-free individuals who have a first-degree relative with a SMI, (c) youth who are experiencing distress and may have mild symptoms of anxiety or depression, and (d) youth who are already demonstrating attenuated symptoms of SMI such as bipolar disorder or psychosis. We will assess, every 6 months for one year, a wide range of clinical and psychosocial factors to determine which factors can be used to predict key outcomes. We will also assess neuroimaging and peripheral markers. We will develop and validate a prediction algorithm that includes demographic, clinical and psychosocial predictors. We will also determine if adding biological markers to our algorithm improves prediction. DISCUSSION: Outcomes from this study include an improved clinical staging model for SMI and prediction algorithms that can be used by health care providers as decision-support tools in their practices. Secondly, we may have a greater understanding of clinical, social and cognitive factors associated with the clinical stages of development of a SMI, as well as new insights from neuroimaging and later neurochemical biomarker studies regarding predisposition to SMI development and progression through the clinical stages of illness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12888-018-1801-0) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6034268
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-60342682018-07-12 Youth at-risk for serious mental illness: methods of the PROCAN study Addington, Jean Goldstein, Benjamin I. Wang, Jian Li Kennedy, Sidney H. Bray, Signe Lebel, Catherine Hassel, Stefanie Marshall, Catherine MacQueen, Glenda BMC Psychiatry Study Protocol BACKGROUND: Most mental disorders begin in adolescence; however, there are gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop a mental illness, what that illness will be, and what can be done to change its course and prevent its worsening to a serious mental illness (SMI). There are also gaps in our understanding of how known risk factors set off neurobiological changes that may play a role in determining who will develop a SMI. Project goals are (i) to identify youth at different stages of risk of SMI so that intervention can begin as soon as possible and (ii) to understand the triggers of these mental illnesses. METHOD: This 2-site longitudinal study will recruit 240 youth, ages 12–25, who are at different stages of risk for developing a SMI. The sample includes (a) healthy individuals, (b) symptom-free individuals who have a first-degree relative with a SMI, (c) youth who are experiencing distress and may have mild symptoms of anxiety or depression, and (d) youth who are already demonstrating attenuated symptoms of SMI such as bipolar disorder or psychosis. We will assess, every 6 months for one year, a wide range of clinical and psychosocial factors to determine which factors can be used to predict key outcomes. We will also assess neuroimaging and peripheral markers. We will develop and validate a prediction algorithm that includes demographic, clinical and psychosocial predictors. We will also determine if adding biological markers to our algorithm improves prediction. DISCUSSION: Outcomes from this study include an improved clinical staging model for SMI and prediction algorithms that can be used by health care providers as decision-support tools in their practices. Secondly, we may have a greater understanding of clinical, social and cognitive factors associated with the clinical stages of development of a SMI, as well as new insights from neuroimaging and later neurochemical biomarker studies regarding predisposition to SMI development and progression through the clinical stages of illness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12888-018-1801-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-07-05 /pmc/articles/PMC6034268/ /pubmed/29976184 http://dx.doi.org/10.1186/s12888-018-1801-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Addington, Jean
Goldstein, Benjamin I.
Wang, Jian Li
Kennedy, Sidney H.
Bray, Signe
Lebel, Catherine
Hassel, Stefanie
Marshall, Catherine
MacQueen, Glenda
Youth at-risk for serious mental illness: methods of the PROCAN study
title Youth at-risk for serious mental illness: methods of the PROCAN study
title_full Youth at-risk for serious mental illness: methods of the PROCAN study
title_fullStr Youth at-risk for serious mental illness: methods of the PROCAN study
title_full_unstemmed Youth at-risk for serious mental illness: methods of the PROCAN study
title_short Youth at-risk for serious mental illness: methods of the PROCAN study
title_sort youth at-risk for serious mental illness: methods of the procan study
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034268/
https://www.ncbi.nlm.nih.gov/pubmed/29976184
http://dx.doi.org/10.1186/s12888-018-1801-0
work_keys_str_mv AT addingtonjean youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT goldsteinbenjamini youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT wangjianli youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT kennedysidneyh youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT braysigne youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT lebelcatherine youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT hasselstefanie youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT marshallcatherine youthatriskforseriousmentalillnessmethodsoftheprocanstudy
AT macqueenglenda youthatriskforseriousmentalillnessmethodsoftheprocanstudy