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MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

BACKGROUND: Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear. METHODS...

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Detalles Bibliográficos
Autores principales:	Yoon, Yi Na, Choe, Min Ho, Jung, Kwan-Young, Hwang, Sang-Gu, Oh, Jeong Su, Kim, Jae-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034325/ https://www.ncbi.nlm.nih.gov/pubmed/29976159 http://dx.doi.org/10.1186/s12885-018-4600-6

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