Cargando…
Chronic obstructive pulmonary disease and the hallmarks of aging
Aging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung patholog...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034372/ https://www.ncbi.nlm.nih.gov/pubmed/29970772 http://dx.doi.org/10.4103/lungindia.lungindia_266_17 |
_version_ | 1783337869082886144 |
---|---|
author | Kukrety, Shweta P. Parekh, Jai D. Bailey, Kristina L. |
author_facet | Kukrety, Shweta P. Parekh, Jai D. Bailey, Kristina L. |
author_sort | Kukrety, Shweta P. |
collection | PubMed |
description | Aging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung pathologies such as chronic obstructive pulmonary disease (COPD). COPD is a disease that develops gradually. Emphysematous changes in the lung take years to develop after exposure to cigarette smoke; hence, the vast majority of patients are elderly. There has been a dramatic increase in the life expectancy of the general population, resulting in an increased burden of chronic lung diseases. There is growing evidence that molecular mechanisms involved in aging may also play a role in COPD pathogenesis. Recently, the nine hallmarks of aging were identified. In this article, we will review the nine hallmarks of aging and how each hallmark contributes to the pathogenesis of COPD. |
format | Online Article Text |
id | pubmed-6034372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60343722018-07-20 Chronic obstructive pulmonary disease and the hallmarks of aging Kukrety, Shweta P. Parekh, Jai D. Bailey, Kristina L. Lung India Review Article Aging is characterized by progressive deterioration of physiological integrity, decline in homeostasis, and degeneration of the tissues that occurs after the reproductive phase of life is complete, leading to impaired function. This deterioration is an important risk factor for chronic lung pathologies such as chronic obstructive pulmonary disease (COPD). COPD is a disease that develops gradually. Emphysematous changes in the lung take years to develop after exposure to cigarette smoke; hence, the vast majority of patients are elderly. There has been a dramatic increase in the life expectancy of the general population, resulting in an increased burden of chronic lung diseases. There is growing evidence that molecular mechanisms involved in aging may also play a role in COPD pathogenesis. Recently, the nine hallmarks of aging were identified. In this article, we will review the nine hallmarks of aging and how each hallmark contributes to the pathogenesis of COPD. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6034372/ /pubmed/29970772 http://dx.doi.org/10.4103/lungindia.lungindia_266_17 Text en Copyright: © 2018 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Kukrety, Shweta P. Parekh, Jai D. Bailey, Kristina L. Chronic obstructive pulmonary disease and the hallmarks of aging |
title | Chronic obstructive pulmonary disease and the hallmarks of aging |
title_full | Chronic obstructive pulmonary disease and the hallmarks of aging |
title_fullStr | Chronic obstructive pulmonary disease and the hallmarks of aging |
title_full_unstemmed | Chronic obstructive pulmonary disease and the hallmarks of aging |
title_short | Chronic obstructive pulmonary disease and the hallmarks of aging |
title_sort | chronic obstructive pulmonary disease and the hallmarks of aging |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034372/ https://www.ncbi.nlm.nih.gov/pubmed/29970772 http://dx.doi.org/10.4103/lungindia.lungindia_266_17 |
work_keys_str_mv | AT kukretyshwetap chronicobstructivepulmonarydiseaseandthehallmarksofaging AT parekhjaid chronicobstructivepulmonarydiseaseandthehallmarksofaging AT baileykristinal chronicobstructivepulmonarydiseaseandthehallmarksofaging |