Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative aff...

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Detalles Bibliográficos
Autores principales: Clulow, James A., Storck, Elisabeth M., Lanyon-Hogg, Thomas, Kalesh, Karunakaran A., Jones, Lyn H., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034444/
https://www.ncbi.nlm.nih.gov/pubmed/28439590
http://dx.doi.org/10.1039/c6cc08797c
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author Clulow, James A.
Storck, Elisabeth M.
Lanyon-Hogg, Thomas
Kalesh, Karunakaran A.
Jones, Lyn H.
Tate, Edward W.
author_facet Clulow, James A.
Storck, Elisabeth M.
Lanyon-Hogg, Thomas
Kalesh, Karunakaran A.
Jones, Lyn H.
Tate, Edward W.
author_sort Clulow, James A.
collection PubMed
description Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
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spelling pubmed-60344442018-07-26 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane Clulow, James A. Storck, Elisabeth M. Lanyon-Hogg, Thomas Kalesh, Karunakaran A. Jones, Lyn H. Tate, Edward W. Chem Commun (Camb) Chemistry Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action. Royal Society of Chemistry 2017-05-07 2017-04-25 /pmc/articles/PMC6034444/ /pubmed/28439590 http://dx.doi.org/10.1039/c6cc08797c Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Clulow, James A.
Storck, Elisabeth M.
Lanyon-Hogg, Thomas
Kalesh, Karunakaran A.
Jones, Lyn H.
Tate, Edward W.
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title_full Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title_fullStr Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title_full_unstemmed Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title_short Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
title_sort competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034444/
https://www.ncbi.nlm.nih.gov/pubmed/28439590
http://dx.doi.org/10.1039/c6cc08797c
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AT lanyonhoggthomas competitionbasedquantitativechemicalproteomicsinbreastcancercellsidentifiesnewtargetprofilesforsulforaphane
AT kaleshkarunakarana competitionbasedquantitativechemicalproteomicsinbreastcancercellsidentifiesnewtargetprofilesforsulforaphane
AT joneslynh competitionbasedquantitativechemicalproteomicsinbreastcancercellsidentifiesnewtargetprofilesforsulforaphane
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