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Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury
BACKGROUND: Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034554/ https://www.ncbi.nlm.nih.gov/pubmed/29904041 http://dx.doi.org/10.12659/MSM.906954 |
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author | Shang, Lei Xu, Yong Shao, Changqing Ma, Chao Feng, Yanbo |
author_facet | Shang, Lei Xu, Yong Shao, Changqing Ma, Chao Feng, Yanbo |
author_sort | Shang, Lei |
collection | PubMed |
description | BACKGROUND: Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL/METHODS: Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10). RESULTS: No significant difference in body weight was observed following the establishment of chronic sports arthritic injury among these 3 groups. Compared with the Vehicle group, Bevacizumab exhibited improved structure of articular cartilage (revealed by HE staining), as well as elevated cartilage content (revealed by Safranin O staining). Moreover, altered cytokines were observed after Bevacizumab treatment, indicating the significant decrease in levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-1, and MMP-3, and a clear increase in levels of transforming growth factor (TGF)-β1. CONCLUSIONS: All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury. |
format | Online Article Text |
id | pubmed-6034554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60345542018-07-10 Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury Shang, Lei Xu, Yong Shao, Changqing Ma, Chao Feng, Yanbo Med Sci Monit Lab/In Vitro Research BACKGROUND: Although a relationship between vascular endothelial growth factor (VEGF) and articular cartilage degeneration has been reported, little is known regarding its role in articular cartilage injury induced by sports activities. In this study, we evaluated the role of VEGF in a rat model of chronic sports arthritic injury. MATERIAL/METHODS: Animals were divided into 3 groups: Control (n=10), Vehicle (chronic sports arthritic injury, n=10), and Bevacizumab (chronic sports arthritic injury treated with anti-VEGF monoclonal antibody Bevacizumab, n=10). RESULTS: No significant difference in body weight was observed following the establishment of chronic sports arthritic injury among these 3 groups. Compared with the Vehicle group, Bevacizumab exhibited improved structure of articular cartilage (revealed by HE staining), as well as elevated cartilage content (revealed by Safranin O staining). Moreover, altered cytokines were observed after Bevacizumab treatment, indicating the significant decrease in levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-1, and MMP-3, and a clear increase in levels of transforming growth factor (TGF)-β1. CONCLUSIONS: All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury. International Scientific Literature, Inc. 2018-06-15 /pmc/articles/PMC6034554/ /pubmed/29904041 http://dx.doi.org/10.12659/MSM.906954 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Lab/In Vitro Research Shang, Lei Xu, Yong Shao, Changqing Ma, Chao Feng, Yanbo Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title | Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title_full | Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title_fullStr | Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title_full_unstemmed | Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title_short | Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury |
title_sort | anti-vascular endothelial growth factor (vegf) antibody ameliorates cartilage degradation in a rat model of chronic sports arthritic injury |
topic | Lab/In Vitro Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034554/ https://www.ncbi.nlm.nih.gov/pubmed/29904041 http://dx.doi.org/10.12659/MSM.906954 |
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