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Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions
The development of electrochemical multisensor systems is driven by the need for fast, miniature, inexpensive, analytical devices, and advanced interdisciplinary based on both chemometric and (nano)material approaches. A multicomponent analysis of complex mixtures in environmental and technological...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034576/ https://www.ncbi.nlm.nih.gov/pubmed/30009159 http://dx.doi.org/10.3389/fchem.2018.00256 |
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author | Nikolaev, Konstantin G. Ermolenko, Yury E. Offenhäusser, Andreas Ermakov, Sergey S. Mourzina, Yulia G. |
author_facet | Nikolaev, Konstantin G. Ermolenko, Yury E. Offenhäusser, Andreas Ermakov, Sergey S. Mourzina, Yulia G. |
author_sort | Nikolaev, Konstantin G. |
collection | PubMed |
description | The development of electrochemical multisensor systems is driven by the need for fast, miniature, inexpensive, analytical devices, and advanced interdisciplinary based on both chemometric and (nano)material approaches. A multicomponent analysis of complex mixtures in environmental and technological monitoring, biological samples, and cell culture requires chip-based multisensor systems with high-stability sensors. In this paper, we describe the development, characterization, and applications of chip-based nanoelectrochemical sensor arrays prepared by the directed electrochemical nanowire assembly (DENA) of noble metals and metal alloys to analyze aqueous solutions. A synergic action of the electrode transducer function and electrocatalytic activity of the nanostructured surface toward analytes is achieved in the assembled metal nanowire (NW) sensors. Various sensor nanomaterials (Pd, Ni, Au, and their multicomponent compositions) can be electrochemically assembled on a single chip without employing multiple cycles of photolithography process to realize multi-analyte sensing applications as well as spatial resolution of sensor analysis by this single-chip multisensor system. For multi-analyte electrochemical sensing, individual amperometric signals of two or more nanowires can be acquired, making use of the specific electrocatalytic surface properties of the individual nanowire sensors of the array toward analytes. To demonstrate the application of a new electrochemical multisensor platform, Pd-Au, Pd-Ni, Pd, and Au NW electrode arrays on a single chip were employed for the non-enzymatic analysis of hydrogen peroxide, glucose, and ethanol. The analytes are determined at low absolute values of the detection potentials with linear concentration ranges of 1.0 × 10(−6) − 1.0 × 10(−3) M (H(2)O(2)), 1.5 × 10(−7) − 2.0 × 10(−3) M (glucose), and 0.7 × 10(−3) − 3.0 × 10(−2) M (ethanol), detection limits of 2 × 10(−7) M (H(2)O(2)), 4 × 10(−8) M (glucose), and 5.2 × 10(−4) M (ethanol), and sensitivities of 18 μA M(−1) (H(2)O(2)), 178 μA M(−1) (glucose), and 28 μA M(−1) (ethanol), respectively. The sensors demonstrate a high level of stability due to the non-enzymatic detection mode. Based on the DENA-assembled nanowire electrodes of a compositional diversity, we propose a novel single-chip electrochemical multisensor platform, which is promising for acquiring complex analytical signals for advanced data processing with chemometric techniques aimed at the development of electronic tongue-type multisensor systems for flexible multi-analyte monitoring and healthcare applications. |
format | Online Article Text |
id | pubmed-6034576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60345762018-07-13 Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions Nikolaev, Konstantin G. Ermolenko, Yury E. Offenhäusser, Andreas Ermakov, Sergey S. Mourzina, Yulia G. Front Chem Chemistry The development of electrochemical multisensor systems is driven by the need for fast, miniature, inexpensive, analytical devices, and advanced interdisciplinary based on both chemometric and (nano)material approaches. A multicomponent analysis of complex mixtures in environmental and technological monitoring, biological samples, and cell culture requires chip-based multisensor systems with high-stability sensors. In this paper, we describe the development, characterization, and applications of chip-based nanoelectrochemical sensor arrays prepared by the directed electrochemical nanowire assembly (DENA) of noble metals and metal alloys to analyze aqueous solutions. A synergic action of the electrode transducer function and electrocatalytic activity of the nanostructured surface toward analytes is achieved in the assembled metal nanowire (NW) sensors. Various sensor nanomaterials (Pd, Ni, Au, and their multicomponent compositions) can be electrochemically assembled on a single chip without employing multiple cycles of photolithography process to realize multi-analyte sensing applications as well as spatial resolution of sensor analysis by this single-chip multisensor system. For multi-analyte electrochemical sensing, individual amperometric signals of two or more nanowires can be acquired, making use of the specific electrocatalytic surface properties of the individual nanowire sensors of the array toward analytes. To demonstrate the application of a new electrochemical multisensor platform, Pd-Au, Pd-Ni, Pd, and Au NW electrode arrays on a single chip were employed for the non-enzymatic analysis of hydrogen peroxide, glucose, and ethanol. The analytes are determined at low absolute values of the detection potentials with linear concentration ranges of 1.0 × 10(−6) − 1.0 × 10(−3) M (H(2)O(2)), 1.5 × 10(−7) − 2.0 × 10(−3) M (glucose), and 0.7 × 10(−3) − 3.0 × 10(−2) M (ethanol), detection limits of 2 × 10(−7) M (H(2)O(2)), 4 × 10(−8) M (glucose), and 5.2 × 10(−4) M (ethanol), and sensitivities of 18 μA M(−1) (H(2)O(2)), 178 μA M(−1) (glucose), and 28 μA M(−1) (ethanol), respectively. The sensors demonstrate a high level of stability due to the non-enzymatic detection mode. Based on the DENA-assembled nanowire electrodes of a compositional diversity, we propose a novel single-chip electrochemical multisensor platform, which is promising for acquiring complex analytical signals for advanced data processing with chemometric techniques aimed at the development of electronic tongue-type multisensor systems for flexible multi-analyte monitoring and healthcare applications. Frontiers Media S.A. 2018-06-29 /pmc/articles/PMC6034576/ /pubmed/30009159 http://dx.doi.org/10.3389/fchem.2018.00256 Text en Copyright © 2018 Nikolaev, Ermolenko, Offenhäusser, Ermakov and Mourzina. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Nikolaev, Konstantin G. Ermolenko, Yury E. Offenhäusser, Andreas Ermakov, Sergey S. Mourzina, Yulia G. Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title | Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title_full | Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title_fullStr | Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title_full_unstemmed | Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title_short | Multisensor Systems by Electrochemical Nanowire Assembly for the Analysis of Aqueous Solutions |
title_sort | multisensor systems by electrochemical nanowire assembly for the analysis of aqueous solutions |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034576/ https://www.ncbi.nlm.nih.gov/pubmed/30009159 http://dx.doi.org/10.3389/fchem.2018.00256 |
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