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Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance
HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in contrast with DP and DR, epitope bindi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034589/ https://www.ncbi.nlm.nih.gov/pubmed/30002966 http://dx.doi.org/10.7717/peerj.5118 |
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author | Manczinger, Máté Kemény, Lajos |
author_facet | Manczinger, Máté Kemény, Lajos |
author_sort | Manczinger, Máté |
collection | PubMed |
description | HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in contrast with DP and DR, epitope binding by DQ variants rather results in immune tolerance. However, the pieces of evidence are limited and controversial. We found that DQ molecules bind more human epitopes than DR. Pathogen-associated epitopes bound by DQ molecules are more similar to human proteins than the ones bound by DR. Accordingly, DQ molecules bind epitopes of significantly different pathogen species. Moreover, the binding of autoimmunity-associated epitopes by DQ confers protection from autoimmune diseases. Our results suggest a special role of HLA-DQ in immune homeostasis and help to better understand the association of HLA molecules with infectious and autoimmune diseases. |
format | Online Article Text |
id | pubmed-6034589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60345892018-07-12 Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance Manczinger, Máté Kemény, Lajos PeerJ Computational Biology HLA class II proteins are important elements of human adaptive immune recognition and are associated with numerous infectious and immune-mediated diseases. These highly variable molecules can be classified into DP, DQ and DR groups. It has been proposed that in contrast with DP and DR, epitope binding by DQ variants rather results in immune tolerance. However, the pieces of evidence are limited and controversial. We found that DQ molecules bind more human epitopes than DR. Pathogen-associated epitopes bound by DQ molecules are more similar to human proteins than the ones bound by DR. Accordingly, DQ molecules bind epitopes of significantly different pathogen species. Moreover, the binding of autoimmunity-associated epitopes by DQ confers protection from autoimmune diseases. Our results suggest a special role of HLA-DQ in immune homeostasis and help to better understand the association of HLA molecules with infectious and autoimmune diseases. PeerJ Inc. 2018-07-03 /pmc/articles/PMC6034589/ /pubmed/30002966 http://dx.doi.org/10.7717/peerj.5118 Text en ©2018 Manczinger and Kemény http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Computational Biology Manczinger, Máté Kemény, Lajos Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title | Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title_full | Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title_fullStr | Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title_full_unstemmed | Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title_short | Peptide presentation by HLA-DQ molecules is associated with the development of immune tolerance |
title_sort | peptide presentation by hla-dq molecules is associated with the development of immune tolerance |
topic | Computational Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034589/ https://www.ncbi.nlm.nih.gov/pubmed/30002966 http://dx.doi.org/10.7717/peerj.5118 |
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