CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G(0)/G(1) to S-phase

ALDH1L1 is a folate-metabolizing enzyme abundant in liver and several other tissues. In human cancers and cell lines derived from malignant tumors, the ALDH1L1 gene is commonly silenced through the promoter methylation. It was suggested that ALDH1L1 limits proliferation capacity of the cell and thus...

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Detalles Bibliográficos
Autores principales: Khan, Qasim A., Pediaditakis, Peter, Malakhau, Yuryi, Esmaeilniakooshkghazi, Amin, Ashkavand, Zahra, Sereda, Valentin, Krupenko, Natalia I., Krupenko, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034817/
https://www.ncbi.nlm.nih.gov/pubmed/29979702
http://dx.doi.org/10.1371/journal.pone.0199699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034817/
https://www.ncbi.nlm.nih.gov/pubmed/29979702
http://dx.doi.org/10.1371/journal.pone.0199699

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