Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes

BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors may have protective effects on diabetic kidney disease (DKD) via specific antioxidant pathways. The DPP-4 inhibitor, linagliptin, was evaluated with the hypothesis that DPP-4 inhibition would ameliorate the development of DKD in a glucose-indepen...

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Detalles Bibliográficos
Autores principales: Spencer, Netanya Y., Yang, Zhihong, Sullivan, Jensyn Cone, Klein, Thomas, Stanton, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034861/
https://www.ncbi.nlm.nih.gov/pubmed/29979777
http://dx.doi.org/10.1371/journal.pone.0200249

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