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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer’s disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase (BACE1), a key enzyme in the pathogenesis of AD, in N...

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Detalles Bibliográficos
Autores principales:	Causevic, Mirsada, Dominko, Kristina, Malnar, Martina, Vidatic, Lea, Cermak, Stjepko, Pigoni, Martina, Kuhn, Peer-Hendrik, Colombo, Alessio, Havas, Daniel, Flunkert, Stefanie, McDonald, Jessica, Gunnersen, Jenny M., Hutter-Paier, Birgit, Tahirovic, Sabina, Windisch, Manfred, Krainc, Dimitri, Lichtenthaler, Stefan F., Hecimovic, Silva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034874/ https://www.ncbi.nlm.nih.gov/pubmed/29979789 http://dx.doi.org/10.1371/journal.pone.0200344

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