Cargando…

Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2-mediated STAT3/PI3K/Akt signaling pathway

Alkali burn is one of the main causes of corneal injury. The inflammation and neovascularization caused by alkali burns aggravate corneal damage, resulting in loss of vision. The aim of the present study was to evaluate the efficacy of xanthatin in the treatment of alkali burn-induced inflammation a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Mei, Zhou, Xue-Zhi, Ye, Lei, Yuan, Qing, Shi, Ce, Zhu, Pei-Wen, Jiang, Nan, Ma, Ming-Yang, Yang, Qi-Chen, Shao, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034915/ https://www.ncbi.nlm.nih.gov/pubmed/29717775 http://dx.doi.org/10.3892/ijmm.2018.3646

Ejemplares similares

Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K‐Akt–mTOR pathway
por: Chen, Huaqing, et al.
Publicado: (2022)

Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
por: Liu, Man, et al.
Publicado: (2019)

Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin
por: Tao, Li, et al.
Publicado: (2013)

Xanthatin Selectively Targets Retinoblastoma by Inhibiting the PLK1-Mediated Cell Cycle
por: Yang, Jie, et al.
Publicado: (2021)

Rhamnazin attenuates inflammation and inhibits alkali burn-induced corneal neovascularization in rats
por: Yu, Yao, et al.
Publicado: (2018)

Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway
por: Cao, Yang, et al.
Publicado: (2017)

Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway
por: Li, Na, et al.
Publicado: (2021)

Xanthatin Alleviates LPS-Induced Inflammatory Response in RAW264.7 Macrophages by Inhibiting NF-κB, MAPK and STATs Activation
por: Liu, Yuanqi, et al.
Publicado: (2022)

VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway
por: Ling, Mingfa, et al.
Publicado: (2021)

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
por: Saraswati, Sarita, et al.
Publicado: (2019)

PI3K/AKT inhibition induces compensatory activation of the MET/STAT3 pathway in non-small cell lung cancer
por: Bian, Chunan, et al.
Publicado: (2018)

MicroRNA-4485 ameliorates severe influenza pneumonia via inhibition of the STAT3/PI3K/AKT signaling pathway
por: Guo, Longfei, et al.
Publicado: (2020)

SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways
por: Huang, Juan, et al.
Publicado: (2023)

Decursin inhibits retinal neovascularization via suppression of VEGFR-2 activation
por: Kim, Jeong Hun, et al.
Publicado: (2009)

Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors
por: Zhao, Tong T., et al.
Publicado: (2010)

Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma
por: Song, Fei, et al.
Publicado: (2020)

Adropin Improves Radiation-Induced Myocardial Injury via VEGFR2/PI3K/Akt Pathway
por: Li, Bingda, et al.
Publicado: (2022)

Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway
por: Wang, Zijie, et al.
Publicado: (2021)

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells
por: Li, Jun-Kui, et al.
Publicado: (2022)

The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways
por: Chiu, Wen-Chin, et al.
Publicado: (2016)

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2021)

Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways
por: Huang, Yanran, et al.
Publicado: (2020)

Outlook on PI3K/AKT/mTOR inhibition in acute leukemia
por: Fransecky, Lars, et al.
Publicado: (2015)

PI3K/Akt/p53 pathway inhibits reovirus infection
por: Zhang, Xiaozhan, et al.
Publicado: (2015)

6″-Debromohamacanthin A, a Bis (Indole) Alkaloid, Inhibits Angiogenesis by Targeting the VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways
por: Kim, Gi Dae, et al.
Publicado: (2013)

Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
por: Goktas, Sertan, et al.
Publicado: (2014)

Topical Timolol Inhibits Corneal Neovascularization in Rabbits
por: KASIRI, Ali, et al.
Publicado: (2017)

PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression
por: Zhu, Manhui, et al.
Publicado: (2016)

Sodium Butyrate Inhibits Neovascularization Partially via TNXIP/VEGFR2 Pathway
por: Xiao, Xiaoqiang, et al.
Publicado: (2020)

The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates
por: Chen, Kuangqi, et al.
Publicado: (2022)

Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway
por: Shan, Hui, et al.
Publicado: (2022)

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA-149-mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways
por: Wang, Ai-Lei, et al.
Publicado: (2018)

Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma
por: Yang, Nan, et al.
Publicado: (2018)

Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis
por: Chen, Chunlin, et al.
Publicado: (2020)

NOV/CCN3 induces cartilage protection by inhibiting PI3K/AKT/mTOR pathway
por: Huang, Xiaojian, et al.
Publicado: (2019)

Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization
por: Cao, Jing, et al.
Publicado: (2019)

Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway
por: Song, Nan, et al.
Publicado: (2020)

Tetrahedral framework nucleic acids inhibit pathological neovascularization and vaso‐obliteration in ischaemic retinopathy via PI3K/AKT/mTOR signalling pathway
por: Zhou, Xiaodi, et al.
Publicado: (2023)

Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2022)

Dexamethasone Inhibits Podocyte Apoptosis by Stabilizing the PI3K/Akt Signal Pathway
por: Yu-Shengyou,, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bc68uvimac2a7sj81qbsg0lvk8