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Human pluripotent reprogramming with CRISPR activators

CRISPR-Cas9-based gene activation (CRISPRa) is an attractive tool for cellular reprogramming applications due to its high multiplexing capacity and direct targeting of endogenous loci. Here we present the reprogramming of primary human skin fibroblasts into induced pluripotent stem cells (iPSCs) usi...

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Detalles Bibliográficos
Autores principales:	Weltner, Jere, Balboa, Diego, Katayama, Shintaro, Bespalov, Maxim, Krjutškov, Kaarel, Jouhilahti, Eeva-Mari, Trokovic, Ras, Kere, Juha, Otonkoski, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035213/ https://www.ncbi.nlm.nih.gov/pubmed/29980666 http://dx.doi.org/10.1038/s41467-018-05067-x

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