Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component of vesicular membrane. Here, we report that PIK3C3 deficiency in zebrafish results in intestinal injury and inflammation. In pik3c3 mutants, gut tube forms b...

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Detalles Bibliográficos
Autores principales: Zhao, Shaoyang, Xia, Jianhong, Wu, Xiuhua, Zhang, Leilei, Wang, Pengtao, Wang, Haiyun, Li, Heying, Wang, Xiaoshan, Chen, Yan, Agnetti, Jean, Li, Yinxiong, Pei, Duanqing, Shu, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035235/
https://www.ncbi.nlm.nih.gov/pubmed/29980668
http://dx.doi.org/10.1038/s41467-018-05105-8

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